Systemic sclerosis

ER Volkmann, K Andréasson, V Smith - The Lancet, 2023 - thelancet.com
Systemic sclerosis, also known as scleroderma, is a rare and complex autoimmune
connective-tissue disease. Once considered an untreatable and unpredictable condition …

[PDF][PDF] One year in review 2021: systemic sclerosis

M Di Battista, S Barsotti, M Orlandi, G Lepri… - Clin Exp …, 2021 - clinexprheumatol.org
Systemic sclerosis is a rare and chronic connective tissue disease with a multifaceted
pathogenesis characterised by heterogeneous multi-organ clinical manifestations. Every …

Efficacy and safety of lenabasum, a cannabinoid type 2 receptor agonist, in a phase 3 randomized trial in diffuse cutaneous systemic sclerosis

R Spiera, M Kuwana, D Khanna… - Arthritis & …, 2023 - Wiley Online Library
Objective This phase 3 study was undertaken to investigate the efficacy and safety of
lenabasum, a cannabinoid type 2 receptor agonist, in patients with diffuse cutaneous …

[PDF][PDF] One year in review 2020: systemic sclerosis

M Orlandi, G Lepri, A Damiani, S Barsotti… - Clin Exp …, 2020 - clinexprheumatol.org
Systemic sclerosis (SSc) is a connective tissue disease characterised by diffuse
microangiopathy and immune dysregulation which ultimately results in widespread fibrosis …

[HTML][HTML] A systematic review on the economic burden of interstitial lung disease and the cost-effectiveness of current therapies

AW Wong, J Koo, CJ Ryerson, M Sadatsafavi… - BMC Pulmonary …, 2022 - Springer
Background The economic burden of interstitial lung disease (ILD) is unknown, limiting
informed resource allocation and planning. We sought to conduct the first systematic review …

[HTML][HTML] Distinct molecular subtypes of systemic sclerosis and gene signature with diagnostic capability

Q Wang, CL Li, L Wu, JY Hu, Q Yu, SX Zhang… - Frontiers in …, 2023 - frontiersin.org
Background As Systemic Sclerosis (SSc) is a connective tissue ailment that impacts various
bodily systems. The study aims to clarify the molecular subtypes of SSc, with the ultimate …

Direct and indirect costs of systemic sclerosis and associated interstitial lung disease: A nationwide population‐based cohort study

M Knarborg, A Løkke, O Hilberg, R Ibsen… - …, 2022 - Wiley Online Library
Background and objective The study aimed to evaluate the direct and indirect costs of
systemic sclerosis (SSc) in cases with and without interstitial lung disease (ILD). Methods …

Mortality in Systemic Sclerosis–Associated Interstitial Lung Disease in Brazil: A Real-Life, Long-Term Follow-up Observational Study

LV de Oliveira Martins, SM Oliveira… - JCR: Journal of …, 2022 - journals.lww.com
Objectives The aim of this study was to identify risk factors associated with mortality in
patients with systemic sclerosis (SSc), particularly those with interstitial lung disease (ILD) …

Healthcare utilization and economic burden in systemic sclerosis: a systematic review

L Martin Calderon, M Chaudhary, JE Pope - Rheumatology, 2022 - academic.oup.com
Abstract Objective Systemic sclerosis (SSc) is characterized by vasculopathy, fibrosis of skin
and internal organs, and autoimmunity with complications including interstitial lung disease …

Progressive pulmonary fibrosis and its impact on survival in systemic sclerosis-related interstitial lung disease

K Morrisroe, D Hansen, W Stevens, L Ross… - …, 2023 - academic.oup.com
Objective To describe the frequency of progressive pulmonary fibrosis (PPF) in an incident
cohort of systemic sclerosis (SSc)-related interstitial lung disease (ILD) and its impact on …