Despite extensive global efforts in the fight against killer infectious diseases, they still cause
one in four deaths worldwide and are important causes of long-term functional disability …

Tuberculosis (TB) remains an infectious disease of global significance and a leading cause
of death in low-and middle-income countries. Significant effort has been directed towards …

Broadly neutralizing monoclonal antibodies (mAbs) are being developed for HIV-1
prevention. Hence, these mAbs and licensed oral pre-exposure prophylaxis (PrEP)(tenofovir …

Background Patients co-infected with advanced HIV and tuberculosis are at risk of
tuberculosis-associated immune reconstitution inflammatory syndrome (IRIS) and death …

Abstract Treatment of multidrug-resistant tuberculosis (MDR-TB) is extremely challenging
due to the virulence of the etiologic strains of Mycobacterium tuberculosis (M. tb), the …

Immune reconstitution inflammatory syndrome (IRIS) is an exaggerated immune response to
a variety of pathogens in response to antiretroviral therapy-mediated recovery of the immune …

Background. The immunopathogenesis of paradoxical tuberculosis-associated immune
reconstitution inflammatory syndrome (TB-IRIS) remains unclear. We determined the …

Objective T‐cell activation independently predicts mortality, poor immune recovery and non‐
AIDS illnesses during combination antiretroviral therapy (c ART). Atorvastatin showed anti …

Objective: To investigate the impact of tuberculosis-associated immune reconstitution
inflammatory syndrome (TB-IRIS) upon immunological recovery and the T-cell compartment …

An immune reconstitution disorder occurs in up to 40% of severely immunodeficient HIV
patients who commence antiretroviral therapy (ART), with an immune reconstitution …