Host-directed therapies for infectious diseases: current status, recent progress, and future prospects
Despite extensive global efforts in the fight against killer infectious diseases, they still cause
one in four deaths worldwide and are important causes of long-term functional disability …
one in four deaths worldwide and are important causes of long-term functional disability …
Microbiome-immune interactions in tuberculosis
Tuberculosis (TB) remains an infectious disease of global significance and a leading cause
of death in low-and middle-income countries. Significant effort has been directed towards …
of death in low-and middle-income countries. Significant effort has been directed towards …
Adults on pre-exposure prophylaxis (tenofovir-emtricitabine) have faster clearance of anti-HIV monoclonal antibody VRC01
Y Huang, L Zhang, S Karuna, P Andrew… - Nature …, 2023 - nature.com
Broadly neutralizing monoclonal antibodies (mAbs) are being developed for HIV-1
prevention. Hence, these mAbs and licensed oral pre-exposure prophylaxis (PrEP)(tenofovir …
prevention. Hence, these mAbs and licensed oral pre-exposure prophylaxis (PrEP)(tenofovir …
Immunological profiling of tuberculosis-associated immune reconstitution inflammatory syndrome and non-immune reconstitution inflammatory syndrome death in HIV …
S Ravimohan, N Tamuhla, AP Steenhoff… - The Lancet Infectious …, 2015 - thelancet.com
Background Patients co-infected with advanced HIV and tuberculosis are at risk of
tuberculosis-associated immune reconstitution inflammatory syndrome (IRIS) and death …
tuberculosis-associated immune reconstitution inflammatory syndrome (IRIS) and death …
Potential of immunomodulatory agents as adjunct host-directed therapies for multidrug-resistant tuberculosis
Abstract Treatment of multidrug-resistant tuberculosis (MDR-TB) is extremely challenging
due to the virulence of the etiologic strains of Mycobacterium tuberculosis (M. tb), the …
due to the virulence of the etiologic strains of Mycobacterium tuberculosis (M. tb), the …
Immune reconstitution inflammatory syndrome associated with pulmonary pathogens
Immune reconstitution inflammatory syndrome (IRIS) is an exaggerated immune response to
a variety of pathogens in response to antiretroviral therapy-mediated recovery of the immune …
a variety of pathogens in response to antiretroviral therapy-mediated recovery of the immune …
Robust Reconstitution of Tuberculosis-Specific Polyfunctional CD4+ T-Cell Responses and Rising Systemic Interleukin 6 in Paradoxical Tuberculosis-Associated …
S Ravimohan, N Tamuhla, K Nfanyana… - Clinical Infectious …, 2016 - academic.oup.com
Background. The immunopathogenesis of paradoxical tuberculosis-associated immune
reconstitution inflammatory syndrome (TB-IRIS) remains unclear. We determined the …
reconstitution inflammatory syndrome (TB-IRIS) remains unclear. We determined the …
Atorvastatin reduces T‐cell activation and exhaustion among HIV‐infected c ART‐treated suboptimal immune responders in U ganda: a randomised crossover …
D Nakanjako, I Ssinabulya, R Nabatanzi… - Tropical medicine & …, 2015 - Wiley Online Library
Objective T‐cell activation independently predicts mortality, poor immune recovery and non‐
AIDS illnesses during combination antiretroviral therapy (c ART). Atorvastatin showed anti …
AIDS illnesses during combination antiretroviral therapy (c ART). Atorvastatin showed anti …
TB-IRIS, T-cell activation, and remodeling of the T-cell compartment in highly immunosuppressed HIV-infected patients with TB
V Haridas, P Pean, LD Jasenosky, Y Madec… - Aids, 2015 - journals.lww.com
Objective: To investigate the impact of tuberculosis-associated immune reconstitution
inflammatory syndrome (TB-IRIS) upon immunological recovery and the T-cell compartment …
inflammatory syndrome (TB-IRIS) upon immunological recovery and the T-cell compartment …
Immune reconstitution disorders in patients with HIV infection: from pathogenesis to prevention and treatment
CC Chang, V Sheikh, I Sereti, MA French - Current HIV/AIDS Reports, 2014 - Springer
An immune reconstitution disorder occurs in up to 40% of severely immunodeficient HIV
patients who commence antiretroviral therapy (ART), with an immune reconstitution …
patients who commence antiretroviral therapy (ART), with an immune reconstitution …