Background Ageing is a highly complex process marked by a temporal cascade of events,
which promote alterations in the normal functioning of an individual organism. The triggers …

Aging is a complex biological process that is inevitable for nearly all organisms. Aging is the
strongest risk factor for development of multiple neurodegenerative disorders, cancer and …

Abstract Lysine-specific demethylase 1 (LSD1), a critical chromatin modulator, functions as
an oncogene by demethylation of H3K4me1/2. The stability of LSD1 is governed by a …

CINAC-patients present renal proximal tubular cell lysosomal lesions which are also
observed in patients experiencing calcineurin inhibitor (CNI) nephrotoxicity, suggesting that …

During the aging process our body becomes less well equipped to deal with cellular stress,
resulting in an increase in unrepaired damage. This causes varying degrees of impaired …

G protein-coupled receptors (GPCRs) and their associated proteins represent one of the
most diverse cellular signaling systems involved in both physiological and …

Aging is a highly complex molecular process, affecting nearly all tissue systems in humans
and is the highest risk factor in developing neurodegenerative disorders such as Alzheimer's …

Biomedical data sets are becoming increasingly larger and a plethora of high-dimensionality
data sets (“Big Data”) are now freely accessible for neurodegenerative diseases, such as …

Complex aging-triggered disorders are multifactorial programs that comprise a myriad of
alterations in interconnected protein networks over a broad range of tissues. It is evident that …

Multiple interventions in the aging process have been discovered to extend the healthspan
of model organisms. Both industry and academia are therefore exploring possible …