Impact of antigenic evolution and original antigenic sin on SARS-CoV-2 immunity
M Aguilar-Bretones, RAM Fouchier… - The Journal of …, 2023 - Am Soc Clin Investig
Infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and
vaccinations targeting the spike protein (S) offer protective immunity against coronavirus …
vaccinations targeting the spike protein (S) offer protective immunity against coronavirus …
“Is Omicron mild”? Testing this narrative with the mutational landscape of its three lineages and response to existing vaccines and therapeutic antibodies
SARS‐CoV‐2 Omicron with its lineages BA. 1, BA. 2, and BA. 3 has triggered a fresh wave
of Covid‐19 infections. Though, Omicron has, so far, produced mild symptoms, its genome …
of Covid‐19 infections. Though, Omicron has, so far, produced mild symptoms, its genome …
[HTML][HTML] A neutralizing epitope on the SD1 domain of SARS-CoV-2 spike targeted following infection and vaccination
J Seow, H Khan, A Rosa, V Calvaresi, C Graham… - Cell Reports, 2022 - cell.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike is the target for
neutralizing antibodies elicited following both infection and vaccination. While extensive …
neutralizing antibodies elicited following both infection and vaccination. While extensive …
A spike-trimer protein-based tetravalent COVID-19 vaccine elicits enhanced breadth of neutralization against SARS-CoV-2 Omicron subvariants and other variants
R Wang, H Huang, C Yu, C Sun, J Ma, D Kong… - Science China Life …, 2023 - Springer
Multivalent vaccines combining crucial mutations from phylogenetically divergent variants
could be an effective approach to defend against existing and future SARS-CoV-2 variants …
could be an effective approach to defend against existing and future SARS-CoV-2 variants …
Broad and potent neutralizing antibodies are elicited in vaccinated individuals following Delta/BA. 1 breakthrough infection
Despite the success of COVID-19 vaccines in preventing infection and/or severe disease,
there has been an increase in SARS-CoV-2 infections in vaccinated individuals owing to the …
there has been an increase in SARS-CoV-2 infections in vaccinated individuals owing to the …
Longitudinal kinetics of neutralizing antibodies against circulating SARS-CoV-2 variants and estimated level of group immunity of booster-vaccinated individuals …
The coronavirus disease 2019 pandemic persisted for 3 years and is now transitioning to
endemicity. We illustrated the change in group immunity induced by vaccination …
endemicity. We illustrated the change in group immunity induced by vaccination …
The effect of Omicron breakthrough infection and extended BNT162b2 booster dosing on neutralization breadth against SARS-CoV-2 variants of concern
C Graham, T Lechmere, A Rehman, J Seow… - PLoS …, 2022 - journals.plos.org
COVID-19 vaccines are playing a vital role in controlling the COVID-19 pandemic. As SARS-
CoV-2 variants encoding mutations in the surface glycoprotein, Spike, continue to emerge …
CoV-2 variants encoding mutations in the surface glycoprotein, Spike, continue to emerge …
Pre-Omicron vaccine breakthrough infection induces superior cross-neutralization against SARS-CoV-2 Omicron BA. 1 compared to infection alone
ES da Silva, M Kohnen, G Gilson, T Staub… - International Journal of …, 2022 - mdpi.com
SARS-CoV-2 variants raise concern because of their high transmissibility and their ability to
evade neutralizing antibodies elicited by prior infection or by vaccination. Here, we …
evade neutralizing antibodies elicited by prior infection or by vaccination. Here, we …
Antibody binding and angiotensin-converting enzyme 2 binding inhibition Is significantly reduced for both the BA. 1 and BA. 2 Omicron variants
D Junker, M Becker, TR Wagner… - Clinical Infectious …, 2023 - academic.oup.com
Background The rapid emergence of the Omicron variant and its large number of mutations
led to its classification as a variant of concern (VOC) by the World Health Organization …
led to its classification as a variant of concern (VOC) by the World Health Organization …
SARS-CoV-2 vaccine alpha and delta variant breakthrough infections are rare and mild but can happen relatively early after vaccination
JK Peter, F Wegner, S Gsponer, F Helfenstein, T Roloff… - Microorganisms, 2022 - mdpi.com
(1) Background: Some COVID-19 vaccine recipients show breakthrough infection. It remains
unknown, which factors contribute to risks and severe outcomes. Our aim was to identify risk …
unknown, which factors contribute to risks and severe outcomes. Our aim was to identify risk …