Anxiety and depression are highly prevalent mental illnesses worldwide and have long
been thought to be closely associated to neurotransmitter modulation. There is growing …

Mounting evidence indicates that inflammatory cytokines contribute to the development of
depression in both medically ill and medically healthy individuals. Cytokines are important …

Therapeutic interventions that incorporate training in mindfulness meditation have become
increasingly popular, but to date, little is known about neural mechanisms associated with …

Anatomical and pharmacological evidence suggests that the dorsal raphe serotonin system
and the ventral tegmental and substantia nigra dopamine system may act as mutual …

The selective serotonin reuptake inhibitors (SSRIs) have emerged as a major therapeutic
advance in psychopharmacology. As a result, the discovery of these agents marks a …

Weight gain during antidepressant treatment can be either a sign of improvement in patients
who have weight loss as a symptom of depression or a residual symptom in patients who …

Background Many psychiatric disorders including schizophrenia, bipolar disorder and major
depression convey an excess burden of cardiovascular morbidity and mortality. The …

Although neurotrophins have been postulated to have antidepressant properties, their effect
on anxiety is not clear. We find that transgenic overexpression of the neurotrophin BDNF has …

Here, we review the neurophysiological and neuroimaging changes that mediation induces
in structural and functional MRI. The available evidence from structural studies suggests that …

The efficacy and safety of flexible dosing with the antidepressant agomelatine (25–50
mg/day) was evaluated in a 6-week, double-blind, randomized, placebo-controlled study …