Obesity has tripled over the past 40 years to become a major public health issue, as it is
linked with increased mortality and elevated risk for various physical and neuropsychiatric …

Obesity and obesity-associated disorders pose a major public health issue worldwide. Apart
from conventional weight loss drugs, next-generation probiotics (NGPs) seem to be very …

Abstract Purpose of Review Obesity is a global health crisis with detrimental effects on all
organ systems leading to worsening disease state and rising costs of care. Persons with …

The high comorbidity between obesity and mental disorders, such as depression and
anxiety, often exacerbates metabolic and neurological symptoms significantly. However …

Pro-opiomelanocortin (POMC) is a prohormone that encodes multiple smaller peptide
hormones within its structure. These peptide hormones can be generated by cleavage of …

The melanocortin-4 receptor (MC4R) is involved in energy homeostasis and is an important
drug target for syndromic obesity. We report the structure of the antagonist SHU9119-bound …

Albeit essential for perpetuation of species, reproduction is an energy-demanding function
that can be adjusted to body metabolic status. Reproductive maturation and function can be …

The regulation of food intake in fish is a complex process carried out through several
different mechanisms in the central nervous system (CNS) with hypothalamus being the …

Background Neuroinflammation and blood-brain barrier (BBB) disruption are two vital
mechanisms of secondary brain injury following intracerebral hemorrhage (ICH). Recently …

Abstract Purpose of Review This review aims to present current information on genes
underlying severe obesity, with the main emphasis on the three genes LEP, LEPR and …