Osteoporosis is an enormous and growing public health problem. Once considered an
inevitable consequence of ageing, it is now eminently preventable and treatable. Ironically …

The gut microbiome is a key regulator of bone health that affects postnatal skeletal
development and skeletal involution. Alterations in microbiota composition and host …

Osteoporosis is the most common metabolic bone disease in the USA and the world. It is a
subclinical condition until complicated by fracture (s). These fractures place an enormous …

Objective The objective is to formulate clinical practice guidelines for the pharmacological
management of osteoporosis in postmenopausal women. Conclusions Evidence from …

Background Although areal bone mineral density (aBMD) assessed by dual-energy x-ray
absorptiometry (DXA) is the clinical standard for determining fracture risk, most older adults …

Background Abdominal and thoracic CT provide a valuable opportunity for osteoporosis
screening regardless of the clinical indication for imaging. Purpose To establish reference …

Background With increasing knowledge about the gut–bone axis, more studies for
treatments based on the regulation of postmenopausal osteoporosis by gut microbes are …

Genetics in model organisms has progressively broken down walls that previously
separated different disciplines of biology. One example of this holistic evolution is the …

Objectives To identify the genetic determinants of fracture risk and assess the role of 15
clinical risk factors on osteoporotic fracture risk. Design Meta-analysis of genome wide …

Context Globally, one in five men aged> 50 years is predicted to experience an osteoporotic
fracture. Because of the treatment gap in osteoporosis and the paucity of bone-forming …