Regulation of gene expression is a complex but highly guided process. While genomic
technologies and computational approaches have allowed high-throughput mapping of cis …

Androgen receptor (AR)-mediated transcription is critical in almost all stages of prostate
cancer (PCa) growth and differentiation. This process involves a complex interplay of …

Fusion-positive rhabdomyosarcoma (FP-RMS) driven by the expression of the PAX3-FOXO1
(P3F) fusion oncoprotein is an aggressive subtype of pediatric rhabdomyosarcoma. FP-RMS …

Despite the therapeutic promise of direct reprogramming, basic principles concerning fate
erasure and the mechanisms to resolve cell identity conflicts remain unclear. To tackle these …

In acute myeloid leukemia (AML), SWI/SNF chromatin remodeling complexes sustain
leukemic identity by driving high levels of MYC. Previous studies have implicated the …

Chondrocyte differentiation controls skeleton development and stature. Here we provide a
comprehensive map of chondrocyte-specific enhancers and show that they provide a …

Tissue damage elicits cell fate switching through a process called metaplasia, but how the
starting cell fate is silenced and the new cell fate is activated has not been investigated in …

Rhabdomyosarcoma (RMS) is a pediatric soft tissue cancer with a lack of precision therapy
options for patients. We hypothesized that with a general paucity of known mutations in …

Pioneer factors are transcription factors sharing the fascinating ability to bind to compact
chromatin and thereby alter its transcriptional fate. Most pioneer factors are known for their …

Histones and transcription factors (TFs) are two important DNA-binding proteins that interact,
compete, and together regulate transcriptional processes in response to diverse internal and …