The blood–brain barrier: structure, regulation, and drug delivery

D Wu, Q Chen, X Chen, F Han, Z Chen… - Signal transduction and …, 2023 - nature.com
Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous
system (CNS) from toxins and pathogens in blood. However, the presence of BBB …

Differential roles of regulatory T cells in Alzheimer's disease

A Jafarzadeh, A Sheikhi, Z Jafarzadeh, M Nemati - Cellular immunology, 2023 - Elsevier
Regulatory T (Treg) cells interact with a variety of resident cells and infiltrated immune cells
in the central nervous system (CNS) to modulate neuroinflammation and …

[HTML][HTML] Effect of dexmedetomidine on postoperative cognitive dysfunction and the T helper 17/regulatory T cell balance in geriatric patients undergoing orthopedic …

W Zhao, J Li, J Wang, M Liu, D Yu - American Journal of …, 2023 - ncbi.nlm.nih.gov
Objectives: To investigate the effect of dexmedetomidine (DEX) on alleviating postoperative
cognitive dysfunction (POCD) and T helper 17 (Th17)/regulatory T cell (Treg) imbalance in …

Protective role of IL-17-producing γδ T cells in a laser-induced choroidal neovascularization mouse model

YH Chang, CH Hsing, CJ Chiu, YR Wu, SM Hsu… - Journal of …, 2023 - Springer
Background Vision loss in patients with wet/exudative age-related macular degeneration
(AMD) is associated with choroidal neovascularization (CNV), and AMD is the leading cause …

Advances in understanding glaucoma pathogenesis: A multifaceted molecular approach for clinician scientists

E Ekici, S Moghimi - Molecular Aspects of Medicine, 2023 - Elsevier
Glaucoma, a leading cause of irreversible blindness worldwide, is a spectrum of
neurodegenerative diseases characterized by the gradual deterioration of retinal ganglion …

Comparative evaluation of antioxidant activity, total phenolic content, anti-inflammatory, and antibacterial potential of Euphorbia-derived functional products

R Benjamaa, H Elbouny, H Errati, A Moujanni… - Frontiers in …, 2024 - frontiersin.org
This study assessed the medicinal properties of Euphorbia resinifera O. Berg (E. resinifera)
and Euphorbia officinarum subsp echinus (Hook. f. and Coss.) Vindt (Euphorbia echinus …

[HTML][HTML] Crosstalk between hypoxic cellular micro-environment and the immune system: a potential therapeutic target for infectious diseases

OC Akinsulie, S Shahzad, SC Ogunleye… - Frontiers in …, 2023 - frontiersin.org
There are overwhelming reports on the promotional effect of hypoxia on the malignant
behavior of various forms of cancer cells. This has been proposed and tested exhaustively in …

Inflammation as common link to progressive neurological diseases

A Dias-Carvalho, SI Sá, F Carvalho, E Fernandes… - Archives of …, 2024 - Springer
Life expectancy has increased immensely over the past decades, bringing new challenges
to the health systems as advanced age increases the predisposition for many diseases. One …

Plasma soluble ST2 levels are higher in neurodegenerative disorders and associated with poorer cognition

YJ Tan, I Siow, SE Saffari, SKS Ting… - Journal of …, 2023 - content.iospress.com
Background: Suppressor of tumorgenicity 2 (ST2) is highly expressed in brain tissue and is a
receptor for interleukin 33 (IL-33). ST2 exists in two forms, a transmembrane receptor (ST2L) …

Engineered biological nanoparticles as nanotherapeutics for tumor immunomodulation

JN Rahmat, J Liu, T Chen, ZH Li, Y Zhang - Chemical Society Reviews, 2024 - pubs.rsc.org
Biological nanoparticles, or bionanoparticles, are small molecules manufactured in living
systems with complex production and assembly machinery. The products of the assembly …