Since the mid-1950s discovery of the first effective antipsychotic medications (APM), we
have only been able to improve the tolerability but not the overall efficacy of currently …

Research on trauma exposure and its consequences has made tremendous progress in
elucidating the role of traumatic life events in the development and maintenance of …

What value do clinical research trials have in psychiatry? The US National Institutes of
Health (NIH) define a clinical trial as “a research study in which one or more human subjects …

Background The tendency to prefer smaller, immediate rewards over larger, delayed
rewards is known as delay discounting (DD). Developmental deviations in DD may be key in …

The increase of mental illness cases around the world can be described as an urgent and
serious global health threat. Around 500 million people suffer from mental disorders, among …

In light of the limitations of dominant psychiatric classification systems such as the
Diagnostic and Statistical Manual of Mental Disorders (DSM), this special section positions …

Psychotherapy is an effective treatment for many common mental health problems, but the
mechanisms of action and processes of change are unclear, perhaps driven by the focus on …

Scientific attempts to identify biomarkers to reliably diagnose mental disorders have thus far
been unsuccessful. This has inspired the Research Domain Criteria (RDoC) approach …

Advances in artificial intelligence (AI) in general and Natural Language Processing (NLP) in
particular are paving the new way forward for the automated detection and prediction of …

Background There is an ongoing discussion about which neurobiological correlates or
symptoms separate the major psychoses (ie Major Depressive Disorder MDD, Bipolar …