Target-responsive DNAzyme probes for luminescence detection and imaging of DNA-modifying enzymes
L Wang, Q Liu, F Ma, C Zhang - TrAC Trends in Analytical Chemistry, 2023 - Elsevier
DNA-modifying enzymes can specifically identify and repair the DNA damages caused by
intrinsic/extrinsic factors, and they play crucial regulation roles in various cellular activities …
intrinsic/extrinsic factors, and they play crucial regulation roles in various cellular activities …
[图书][B] Molecular biology of human cancers
WA Schulz - 2023 - Springer
viii everybody who contributed to the first edition. As always, I have to thank my wife and
family for encouragement and support (as well as patience…). I hope you will find this book …
family for encouragement and support (as well as patience…). I hope you will find this book …
XPF interacts with TOP2B for R-loop processing and DNA looping on actively transcribed genes
G Chatzinikolaou, K Stratigi, A Siametis… - Science …, 2023 - science.org
Co-transcriptional RNA-DNA hybrids can not only cause DNA damage threatening genome
integrity but also regulate gene activity in a mechanism that remains unclear. Here, we show …
integrity but also regulate gene activity in a mechanism that remains unclear. Here, we show …
The role of TOP2A in immunotherapy and vasculogenic mimicry in non-small cell lung cancer and its potential mechanism
J Wu, L Zhang, W Li, L Wang, Q Jia, F Shi, K Li… - Scientific Reports, 2023 - nature.com
Abstract Type IIA topoisomerase (TOP2A) is significantly associated with malignant tumor
development, invasion, treatment and its prognosis, and has been shown to be a therapeutic …
development, invasion, treatment and its prognosis, and has been shown to be a therapeutic …
RAD54L2-mediated DNA damage avoidance pathway specifically preserves genome integrity in response to topoisomerase 2 poisons
Type II topoisomerases (TOP2) form transient TOP2 cleavage complexes (TOP2ccs) during
their catalytic cycle to relieve topological stress. TOP2ccs are covalently linked TOP2-DNA …
their catalytic cycle to relieve topological stress. TOP2ccs are covalently linked TOP2-DNA …
TOP2A modulates signaling via the AKT/mTOR pathway to promote ovarian cancer cell proliferation
K Zhang, X Zheng, Y Sun, X Feng, X Wu… - Cancer Biology & …, 2024 - Taylor & Francis
Ovarian cancer (OC) is a form of gynecological malignancy that is associated with worse
patient outcomes than any other cancer of the female reproductive tract. Topoisomerase II α …
patient outcomes than any other cancer of the female reproductive tract. Topoisomerase II α …
[HTML][HTML] Single-cell RNA-seq reveals intratumoral heterogeneity in osteosarcoma patients: A review
DD Thomas, RA Lacinski, BA Lindsey - Journal of Bone Oncology, 2023 - Elsevier
While primary bone malignancies make up just 0.2% of all cancers, osteosarcoma (OS) is
the third most common cancer in adolescents. Due to its highly complex and heterogeneous …
the third most common cancer in adolescents. Due to its highly complex and heterogeneous …
DNA double-stranded breaks, a hallmark of aging, defined at the nucleotide resolution, are increased and associated with transcription in the cardiac myocytes in …
B Cathcart, SM Cheedipudi, L Rouhi… - Cardiovascular …, 2024 - academic.oup.com
Aims An intrinsic feature of gene transcription is the formation of DNA superhelices near the
transcription bubble, which are resolved upon induction of transient double-stranded breaks …
transcription bubble, which are resolved upon induction of transient double-stranded breaks …
Molecular differences in renal cell carcinoma between males and females
Purpose The disparity in renal cell carcinoma (RCC) risk and treatment outcome between
males and females is well documented, but the underlying molecular mechanisms remain …
males and females is well documented, but the underlying molecular mechanisms remain …