Gut microbiome and its role in colorectal cancer

M Rebersek - BMC cancer, 2021 - Springer
Colorectal cancer (CRC) is still one of the most common types of cancer in the world, and
the gut microbiome plays an important role in its development. The microbiome is involved …

The role of the gut microbiome in colorectal cancer development and therapy response

L Sánchez-Alcoholado, B Ramos-Molina, A Otero… - Cancers, 2020 - mdpi.com
Colorectal cancer (CRC) is the third most common cancer worldwide and the leading cause
of cancer-related deaths. Recently, several studies have demonstrated that gut microbiota …

Commensal Clostridiales strains mediate effective anti-cancer immune response against solid tumors

A Montalban-Arques, E Katkeviciute, P Busenhart… - Cell host & …, 2021 - cell.com
Despite overall success, T cell checkpoint inhibitors for cancer treatment are still only
efficient in a minority of patients. Recently, intestinal microbiota was found to critically …

Berberine regulates short-chain fatty acid metabolism and alleviates the colitis-associated colorectal tumorigenesis through remodeling intestinal flora

S Yan, J Chang, X Hao, J Liu, X Tan, Z Geng, Z Wang - Phytomedicine, 2022 - Elsevier
Background Colitis-associated cancer (CAC) is known to be a complex combination of tumor
cells, non-tumor cells and a large intestinal flora. The increasing role of intestinal flora in …

[HTML][HTML] Mucosal biofilms are an endoscopic feature of irritable bowel syndrome and ulcerative colitis

M Baumgartner, M Lang, H Holley, D Crepaz… - Gastroenterology, 2021 - Elsevier
Background & Aims Irritable bowel syndrome (IBS) and inflammatory bowel diseases result
in a substantial reduction in quality of life and a considerable socioeconomic impact. In IBS …

Progress in understanding the IL-6/STAT3 pathway in colorectal cancer

Y Lin, Z He, J Ye, Z Liu, X She, X Gao… - OncoTargets and …, 2020 - Taylor & Francis
As a pleiotropic cytokine, interleukin-6 (IL-6) not only regulates the cellular immune
response, but it also promotes tumor development by activating multiple carcinogenic …

Alterations in the gut microbiota and their metabolites in colorectal cancer: recent progress and future prospects

J Li, A Zhang, F Wu, X Wang - Frontiers in Oncology, 2022 - frontiersin.org
Colorectal cancer (CRC) is a leading cause of cancer morbidity and mortality worldwide.
The etiology and pathogenesis of CRC remain unclear. A growing body of evidence …

Gut microbiota and colorectal cancer development: a closer look to the adenoma-carcinoma sequence

M Vacante, R Ciuni, F Basile, A Biondi - Biomedicines, 2020 - mdpi.com
There is wide evidence that CRC could be prevented by regular physical activity, keeping a
healthy body weight, and following a healthy and balanced diet. Many sporadic CRCs …

[HTML][HTML] Unraveling the function of epithelial-mesenchymal transition (EMT) in colorectal cancer: Metastasis, therapy response, and revisiting molecular pathways

E Sabouni, MM Nejad, S Mojtabavi… - Biomedicine & …, 2023 - Elsevier
Colorectal cancer (CRC) is a dangerous form of cancer that affects the gastrointestinal tract.
It is a major global health concern, and the aggressive behavior of tumor cells makes it …

Use of the synbiotic VSL# 3 and yacon-based concentrate attenuates intestinal damage and reduces the abundance of Candidatus Saccharimonas in a colitis …

BC dos Santos Cruz, LL da Conceicao… - Food research …, 2020 - Elsevier
Individuals with inflammatory bowel disease are at high risk of developing colitis-associated
cancer; thus, strategies to inhibit disease progression should be investigated. The study …