Targeting Th17 cells in HIV-1 remission/cure interventions

A Fert, LR Marchand, TRW Salinas, P Ancuta - Trends in Immunology, 2022 - cell.com
Since the discovery of HIV-1, progress has been made in deciphering the viral replication
cycle and mechanisms of host–pathogen interactions that has facilitated the implementation …

Implication of ABC transporters in non-proliferative diseases

TA Grigoreva, AV Sagaidak, DS Novikova… - European Journal of …, 2022 - Elsevier
ABC transporters play an essential role in the development of multidrug resistance and thus
are of interest in the context of anticancer therapy. However, MDR1, BCRP and MRP1 are …

[HTML][HTML] Oral Administration of Flavonifractor plautii, a Bacteria Increased With Green Tea Consumption, Promotes Recovery From Acute Colitis in Mice via …

A Mikami, T Ogita, F Namai, S Shigemori, T Sato… - Frontiers in …, 2021 - frontiersin.org
Flavonifractor plautii (FP) has been reported to participate in the metabolism of catechins in
the human gut. However, there is limited information on the immune regulatory effects of this …

[HTML][HTML] Pharmacogenetic Study of the Impact of ABCB1 Single Nucleotide Polymorphisms on the Response to Cyclosporine in Psoriasis Patients

A Chernov, D Kilina, T Smirnova, E Galimova - Pharmaceutics, 2022 - mdpi.com
Psoriasis is a chronic, T cell-mediated skin disease affecting 2–3% of the Caucasian
population. Cyclosporine A is a calcineurin inhibitor that acts selectively on T cells. The …

[HTML][HTML] The effects of safinamide on dysphagia in Parkinson's disease

M Hirano, M Samukawa, C Isono, Y Nagai - Plos one, 2023 - journals.plos.org
Dysphagia is a potentially fatal symptom of Parkinson's disease (PD) and is characterized by
frequent silent aspiration, a risk factor for aspiration pneumonia. The transdermal dopamine …

Perturbed mitochondrial dynamics, an emerging aspect of epithelial-microbe interactions

DM McKay, NL Mancini, J Shearer… - American Journal of …, 2020 - journals.physiology.org
Mitochondria exist in a complex network that is constantly remodeling via the processes of
fission and fusion in response to intracellular conditions and extracellular stimuli. Excessive …

Comparative pharmacokinetics of the main active components in normal and ulcerative colitis rats after oral administration of Zingiberis Rhizoma–Ginseng Radix et …

Y Wan, Z Dong, H Li, L Yang, W Li… - Journal of …, 2022 - Wiley Online Library
Zingiberis Rhizoma and Ginseng Radix et Rhizoma are usually used together for the
treatment of ulcerative colitis in clinical practices. However, their compatibility mechanism …

[HTML][HTML] ATP-binding cassette transporters in the clinical implementation of pharmacogenetics

LA López-Fernández - Journal of Personalized Medicine, 2018 - mdpi.com
ATP-binding cassette (ABC) transporters are involved in a large number of processes and
contribute to various human genetic diseases. Among other functions, ABC proteins are …

[HTML][HTML] Swine dysentery disease mechanism: Brachyspira hampsonii impairs the colonic immune and epithelial repair responses to induce lesions

MO Costa, JCS Harding - Microbial Pathogenesis, 2020 - Elsevier
Swine dysentery (SD) is a global, production-limiting disease of pigs in commercial farms. It
is associated with infection by Brachyspira hyodysenteriae and B. hampsonii, and …

ABC transporters Mdr1a/1b, Bcrp1, Mrp2 and Mrp3 determine the sensitivity to PhIP/DSS-induced colon carcinogenesis and inflammation

S Durmus, M Van der Valk, SF Teunissen, JY Song… - Archives of …, 2019 - Springer
Amino-1-methyl-6-phenylimidazo [4, 5-b] pyridine (PhIP) is an abundant dietary carcinogen,
formed during high-temperature cooking of meat. In this study, we investigated whether …