New blood vessels formation from the existing vasculature is called angiogenesis. It is an
essential physiological process for the growth of cells, tissue repair, wound healing, and …

Click chemistry is universally recognized as a powerful strategy for the fast and precise
assembly of diverse building blocks. Targeted Protein Degradation (TPD) is a new …

Inhibition of angiogenesis is a promising strategy for the treatment of cancer. Herein, we
describe the design and synthesis of thieno [2, 3-d] pyrimidine-1, 3, 4-thiadiazole-aryl urea …

A new series of isoxazolyl and thiazolyl urea derivatives was synthesized, fully characterized
and evaluated in vitro as anticancer agents. The chemistry involves a facile protocol for the …

Anti-angiogenesis has been proved to be an effective strategy for the treatment of tumors.
Anti-angiogenic drugs had achieved certain therapeutic effects. However, drug resistance …

Our recent investigation is focused on the discovery of anti-angiogenesis agents. Vascular
normalization induced by anti-angiogenic agent appears to be a promising strategy. We …

Abstract VEGFR-2, TIE-2, and EphB4 are essential for both angiogenesis and
tumorigenesis. Herein, we designed and prepared three classes of multi-target inhibitors …

Receptor tyrosine kinases (RTKs), especially VEGFR-2, TIE-2, and EphB4, play a crucial
role in both angiogenesis and tumorigenesis. Moreover, complexity and heterogeneity of …

Modified purine derivatives exemplified by pyrazolopyrimidines have emerged as highly
selective inhibitors of several angiogenic receptor tyrosine kinases. Herein, we designed …

Angiogenesis is modulated by a multitude of pro-angiogenic factors including VEGFR-2, Tie-
2, and EphB4. Moreover, their crosstalk also had been well elaborated. We have identified …