The functions, purposes, and roles of metallothioneins have been the subject of
speculations since the discovery of the protein over 60 years ago. This article guides …

Metallothioneins (MTs) are small cysteine-rich proteins that play important roles in metal
homeostasis and protection against heavy metal toxicity, DNA damage, and oxidative stress …

Single-cell transcriptomics has allowed unprecedented resolution of cell types/states in the
human lung, but their spatial context is less well defined. To (re) define tissue architecture of …

In the last decade, we witnessed discoveries that established Zn2+ as a second major
signalling metal ion in the transmission of information within cells and in communication …

Cadmium (Cd) is a food-chain contaminant that has high rates of soil-to-plant transference.
This phenomenon makes dietary Cd intake unavoidable. Although long-term Cd intake …

Zinc (Zn) is an essential micronutrient and cofactor for up to 10% of proteins in living
organisms. During Zn limitation, specialized enzymes called metallochaperones are …

MT1 has been demonstrated to be an essential stress protein in maintaining physiological
balance and regulating immune homeostasis. While the immunological involvement of MT1 …

The importance of zinc as a trace metal in the human body has long been overlooked. We
now gradually discover that the impact of zinc on the health of our body might be as far …

The persistence of heavy metals (HMs) in the environment causes adverse effects to all
living organisms; HMs accumulate along the food chain affecting different levels of biological …

Zinc (II) ions are redox-inert in biology. Yet, their interaction with sulfur of cysteine in cellular
proteins can confer ligand-centered redox activity on zinc coordination sites, control protein …