Precise plant genome editing using base editors and prime editors
The development of CRISPR–Cas systems has sparked a genome editing revolution in
plant genetics and breeding. These sequence-specific RNA-guided nucleases can induce …
plant genetics and breeding. These sequence-specific RNA-guided nucleases can induce …
Genome editing with CRISPR–Cas nucleases, base editors, transposases and prime editors
The development of new CRISPR–Cas genome editing tools continues to drive major
advances in the life sciences. Four classes of CRISPR–Cas-derived genome editing agents …
advances in the life sciences. Four classes of CRISPR–Cas-derived genome editing agents …
Discovery of deaminase functions by structure-based protein clustering
J Huang, Q Lin, H Fei, Z He, H Xu, Y Li, K Qu, P Han… - Cell, 2023 - cell.com
The elucidation of protein function and its exploitation in bioengineering have greatly
advanced the life sciences. Protein mining efforts generally rely on amino acid sequences …
advanced the life sciences. Protein mining efforts generally rely on amino acid sequences …
CRISPR/Cas genome editing and precision plant breeding in agriculture
K Chen, Y Wang, R Zhang, H Zhang… - Annual review of plant …, 2019 - annualreviews.org
Enhanced agricultural production through innovative breeding technology is urgently
needed to increase access to nutritious foods worldwide. Recent advances in CRISPR/Cas …
needed to increase access to nutritious foods worldwide. Recent advances in CRISPR/Cas …
Novel CRISPR–Cas systems: an updated review of the current achievements, applications, and future research perspectives
According to Darwin's theory, endless evolution leads to a revolution. One such example is
the Clustered Regularly Interspaced Palindromic Repeats (CRISPR)–Cas system, an …
the Clustered Regularly Interspaced Palindromic Repeats (CRISPR)–Cas system, an …
Current status and future prospects in cannabinoid production through in vitro culture and synthetic biology
For centuries, cannabis has been a rich source of fibrous, pharmaceutical, and recreational
ingredients. Phytocannabinoids are the most important and well-known class of cannabis …
ingredients. Phytocannabinoids are the most important and well-known class of cannabis …
CRISPR/Cas-mediated base editing: technical considerations and practical applications
Genome editing with CRISPR/Cas has rapidly gained popularity. Base editing, a new
CRISPR/Cas-based approach, can precisely convert one nucleotide to another in DNA or …
CRISPR/Cas-based approach, can precisely convert one nucleotide to another in DNA or …
Precision genome editing using cytosine and adenine base editors in mammalian cells
Genome editing has transformed the life sciences and has exciting prospects for use in
treating genetic diseases. Our laboratory developed base editing to enable precise and …
treating genetic diseases. Our laboratory developed base editing to enable precise and …
Gene editing in plants: progress and challenges
Y Mao, JR Botella, Y Liu, JK Zhu - National Science Review, 2019 - academic.oup.com
The clustered regularly interspaced short palindromic repeat (CRISPR)-associated protein 9
(Cas9) genome editing system is a powerful tool for targeted gene modifications in a wide …
(Cas9) genome editing system is a powerful tool for targeted gene modifications in a wide …
Generation of herbicide tolerance traits and a new selectable marker in wheat using base editing
R Zhang, J Liu, Z Chai, S Chen, Y Bai, Y Zong, K Chen… - Nature plants, 2019 - nature.com
Developing herbicide-tolerant varieties by genome editing holds great promise for
addressing the worsening weed problems in wheat cultivation. Here, we generated …
addressing the worsening weed problems in wheat cultivation. Here, we generated …