Targeting immune cell circuits and trafficking in inflammatory bowel disease
MF Neurath - Nature immunology, 2019 - nature.com
Inflammatory bowel diseases (IBDs) such as Crohn's disease and ulcerative colitis are
characterized by uncontrolled activation of intestinal immune cells in a genetically …
characterized by uncontrolled activation of intestinal immune cells in a genetically …
Current and emerging therapeutic targets for IBD
MF Neurath - Nature Reviews Gastroenterology & Hepatology, 2017 - nature.com
Various therapeutic advances have led to a paradigm shift in the clinical management of
patients with IBD. The introduction of immunosuppressive (such as azathioprine) and …
patients with IBD. The introduction of immunosuppressive (such as azathioprine) and …
Tumor necrosis factor inhibitors for inflammatory bowel disease
OH Nielsen, MA Ainsworth - New England Journal of Medicine, 2013 - Mass Medical Soc
Tumor Necrosis Factor Inhibitors for Inflammatory Bowel Disease | New England Journal of
Medicine Skip to main content The New England Journal of Medicine homepage Advanced …
Medicine Skip to main content The New England Journal of Medicine homepage Advanced …
Systematic review of effects of withdrawal of immunomodulators or biologic agents from patients with inflammatory bowel disease
Little is known about the optimal duration of therapy with an anti–tumor necrosis factor (TNF)
agent and/or an immunomodulator for patients with inflammatory bowel disease (IBD). We …
agent and/or an immunomodulator for patients with inflammatory bowel disease (IBD). We …
One‐year clinical outcomes with biologics in Crohn's disease: transmural healing compared with mucosal or no healing
F Castiglione, N Imperatore, A Testa… - Alimentary …, 2019 - Wiley Online Library
Background While mucosal healing has been proved to predict relevant clinical outcomes in
Crohn's disease (CD), little is known about the long‐term significance of transmural healing …
Crohn's disease (CD), little is known about the long‐term significance of transmural healing …
Development of an algorithm incorporating pharmacokinetics of adalimumab in inflammatory bowel diseases
X Roblin, M Rinaudo, E Del Tedesco… - Official journal of the …, 2014 - journals.lww.com
OBJECTIVES: Several decision algorithms based on the measurement of infliximab (IFX)
trough levels and antibodies to IFX have been proposed. Whether such algorithms can be …
trough levels and antibodies to IFX have been proposed. Whether such algorithms can be …
The future of biosimilars: maximizing benefits across immune-mediated inflammatory diseases
Biologics have transformed the treatment of immune-mediated inflammatory diseases such
as rheumatoid arthritis (RA) and inflammatory bowel disease (IBD). Biosimilars—biologic …
as rheumatoid arthritis (RA) and inflammatory bowel disease (IBD). Biosimilars—biologic …
Management of non-response and loss of response to anti-tumor necrosis factor therapy in inflammatory bowel disease
J Marsal, M Barreiro-de Acosta, I Blumenstein… - Frontiers in …, 2022 - frontiersin.org
Anti-tumor necrosis factor (anti-TNF) therapy has been successfully used as first-line
biologic treatment for moderate-to-severe inflammatory bowel disease (IBD), in both “step …
biologic treatment for moderate-to-severe inflammatory bowel disease (IBD), in both “step …
Treating beyond symptoms with a view to improving patient outcomes in inflammatory bowel diseases
WJ Sandborn, S Hanauer, G Van Assche… - Journal of Crohn's …, 2014 - academic.oup.com
Background and aims Treatment goals in inflammatory bowel diseases are evolving beyond
the control of symptoms towards the tight control of objectively-measured gastrointestinal …
the control of symptoms towards the tight control of objectively-measured gastrointestinal …
[HTML][HTML] Dysbiosis of gut microbiota in inflammatory bowel disease: Current therapies and potential for microbiota-modulating therapeutic approaches
There is a growing body of evidence reinforcing the unique connections between the host
microbiome, health, and diseases. Due to the extreme importance of the symbiotic …
microbiome, health, and diseases. Due to the extreme importance of the symbiotic …