The Ccr4–Not complex is a unique, essential and conserved multi-subunit complex that acts
at the level of many different cellular functions to regulate gene expression. Two enzymatic …

Ess1 is a prolyl isomerase that regulates the structure and function of eukaryotic RNA
polymerase II. Ess1 works by catalyzing the cis/trans conversion of pSer5–Pro6 bonds, and …

We measure transcriptional noise in yeast by analyzing chromatin structure and transcription
of an 18-kb region of DNA whose sequence was randomly generated. Nucleosomes fully …

Numerous noncoding transcripts of unknown function have recently been identified. In this
study, we report a novel mechanism that relies on transcription of noncoding RNA prt (pho1 …

Background: Dbp2 is a member of the DEAD-box family of RNA helicases. Results: Dbp2 is
a double-stranded RNA-specific ATPase required for repression of cryptic initiation and …

Non-coding RNAs (ncRNAs) play critical roles in gene regulation. In eukaryotic cells,
ncRNAs are processed and/or degraded by the nuclear exosome, a ribonuclease complex …

Nuclear noncoding RNA (ncRNA) surveillance pathways play key roles in shaping the
steady-state transcriptomes of eukaryotic cells. Defective and unneeded ncRNAs are …

Cryptic transcription, the initiation of transcription from non-promoter regions within a gene
body, is a type of transcriptional dysregulation that occurs throughout eukaryotes. In …

PIWI family proteins have recently emerged as essential contributors in numerous biological
processes including germ cell development, stem cell maintenance and epigenetic …

The histone H3 variant H3. 3 is a highly conserved and dynamic regulator of chromatin
organization. Therefore, fully elucidating its nucleosome incorporation mechanisms is …