[HTML][HTML] The importance of the pyrazole scaffold in the design of protein kinases inhibitors as targeted anticancer therapies

GM Nitulescu, G Stancov, OC Seremet, G Nitulescu… - Molecules, 2023 - mdpi.com
The altered activation or overexpression of protein kinases (PKs) is a major subject of
research in oncology and their inhibition using small molecules, protein kinases inhibitors …

Pyrazole: An emerging privileged scaffold in drug discovery

MA Alam - Future medicinal chemistry, 2023 - Taylor & Francis
Pyrazole or 1 H-pyrazole, a five-membered 1, 2-diazole, is found in several approved drugs
and some bioactive natural products. A myriad number of derivatives of this small molecule …

[HTML][HTML] Novel 5-aminopyrazoles endowed with anti-angiogenetic properties: Design, synthesis and biological evaluation

M Lusardi, B Wehrle-Haller, A Sidibe, M Ponassi… - European Journal of …, 2023 - Elsevier
The promising anti-angiogenetic properties of previously synthesized pyrazolyl ureas
provided the rationale for the synthesis of novel 5-aminopyrazoles 2–5, differently decorated …

Recent drug design strategies and identification of key heterocyclic scaffolds for promising anticancer targets

A Mushtaq, P Wu, MM Naseer - Pharmacology & Therapeutics, 2023 - Elsevier
Cancer, a noncommunicable disease, is the leading cause of mortality worldwide and is
anticipated to rise by 75% in the next two decades, reaching approximately 25 million cases …

[HTML][HTML] Tumor associated carbonic anhydrase inhibitors: rational approaches, design strategies, structure activity relationship and mechanistic insights

SG Nerella, PS Thacker, M Arifuddin… - European Journal of …, 2024 - Elsevier
The emergence of tumor-associated human carbonic anhydrases (hCA) as promising
therapeutic targets has urged rigorous research into the development of potent and selective …

[HTML][HTML] Developments and applications of α-bromonitrostyrenes in organic syntheses

F Doraghi, MMA Ashtiani, F Moradkhani, B Larijani… - RSC …, 2024 - pubs.rsc.org
The presence of the bromo and nitro groups in the structure of α-bromonitrostyrene makes
them highly reactive and versatile reagents in organic syntheses. α-Bromonitrostyrenes act …

Extraction of Uranium by a Pyrazole-Based Porous Organic Polymer

K Yu, L Zhong, L Guo, F Gao, X Feng, F Luo - Inorganic Chemistry, 2024 - ACS Publications
In this work, we report a pyrazole-based porous organic polymer (namely, ECUT-POP-2) for
extraction of uranium. ECUT-POP-2 affords a high uranium extraction capacity of up to 1851 …

2-(allylthio)-5-(5-phenyl-1H-pyrazol-3-yl)-1, 3, 4-oxadiazole: Synthesis, single crystal XRD, spectroscopic characterization, antidiabetic activity, DFT and ADMET …

IA El Hassani, SA Brandán, S Mortada, S Arshad… - Journal of Molecular …, 2024 - Elsevier
Here, we synthesized a new potent antidiabetic agent of pyrazolyl-1, 3, 4-oxadiazole
derivative, named 2-(allylthio)-5-(5-phenyl-1H-pyrazol-3-yl)-1, 3, 4-oxadiazole (ATPO) and …

[HTML][HTML] Pyrazole-vaniline Schiff base disperse azo dyes for UV protective clothing: synthesis, characterization, comparative study of UPF, dyeing properties and …

AA Noser, SA Ibrahim, HA Abd El Salam… - Journal of the Iranian …, 2023 - Springer
From 5-amino pyrazole, azo disperse pyrazole dyes containing o-vanillin have been
synthesized and characterized using elemental analyses and Spectroscopic techniques. All …

Aryliodonium Salt-Induced Regioselective Access to meta-Substituted Anilines by Arylation of Azoles

Y He, Y Li, X Ma, X Zhou, Y Huang… - The Journal of Organic …, 2024 - ACS Publications
A highly efficient aryliodonium salt-induced regioselective access to meta-substituted
anilines by arylation of azoles has been developed under catalyst-free conditions. This …