Individualization of vancomycin dosing based on therapeutic drug monitoring (TDM) data is
known to improve patient outcomes compared with fixed or empirical dosing strategies …

Beta-lactams (BL) are the first line agents for the antibiotic management of critically ill
patients with sepsis or septic shock. BL are hydrophilic antibiotics particularly subject to …

Abstract Model‐informed precision dosing (MIPD) approaches typically apply maximum a
posteriori (MAP) Bayesian estimation to determine individual pharmacokinetic (PK) …

Critically ill patients admitted to intensive care unit (ICU) with severe infections, or those who
develop nosocomial infections, have poor outcomes with substantial morbidity and mortality …

Older adults, the fastest growing population, represent almost 50% of all users of direct oral
anticoagulants (DOACs). Unfortunately, we have very little relevant pharmacological and …

Cytomegalovirus infection during antiviral prophylaxis occurs in transplant recipients despite
individualized regimens based on renal function. Fifty kidney transplant recipients were …

Vancomycin is a hydrophilic antibiotic widely used in severe infections, including bacteremia
and central nervous system (CNS) infections caused by Gram-positive bacteria such as …

Objectives Few studies have explored the factors influencing user uptake of interventions
designed to enhance therapeutic drug monitoring (TDM). This study aimed to identify …

For most drugs today, there is a single dose level recommended for most patients with the
exception of well characterised situations such as different ages or ethnicities, the presence …

We aimed to evaluate the predictive performance and predicted doses of a single-model
approach or several multi-model approaches compared with the standard therapeutic drug …