Unveiling the Crucial Roles of O2•– and ATP in Hepatic Ischemia–Reperfusion Injury Using Dual-Color/Reversible Fluorescence Imaging

J Liu, W Zhang, X Wang, Q Ding, C Wu… - Journal of the …, 2023 - ACS Publications
Hepatic ischemia–reperfusion injury (HIRI) is mainly responsible for morbidity or death due
to graft rejection after liver transplantation. During HIRI, superoxide anion (O2•–) and …

A mitochondria-targeted H2S-activatable fluorogenic probe for tracking hepatic ischemia-reperfusion injury

B Fang, J Yang, L Wang, H Li, J Guo, J Zhang… - Chinese Chemical …, 2024 - Elsevier
Hepatic ischemia-reperfusion injury (HIRI) is the cause of postoperative hepatic dysfunction
and failure, and even death. As an important biological effector molecule, hydrogen sulfide …

Lipid droplets, autophagy, and ER stress as key (survival) pathways during ischemia‐reperfusion of transplanted grafts

D Kamińska, M Skrzycki - Cell Biology International, 2024 - Wiley Online Library
Ischemia‐reperfusion injury is an event concerning any organ under a procedure of
transplantation. The early result of ischemia is hypoxia, which causes malfunction of …

Icaritin attenuates ischemia–reperfusion injury by anti-inflammation, anti-oxidative stress, and anti-autophagy in mouse liver

Q Sun, R Yang, S Li, H Wang, D Kong, W Zhang… - International …, 2024 - Elsevier
Background Hepatic ischemia–reperfusion (IR) injury is a major complication of liver
transplantation and gravely affects patient prognosis. Icaritin (ICT), the primary plasma …

PPARβ/δ activation protects against hepatic ischaemia–reperfusion injury

B Qian, C Wang, X Li, P Ma, L Dong, B Shen… - Liver …, 2023 - Wiley Online Library
Abstract Background and Aims Hepatic ischaemia/reperfusion injury (HIRI) is a
pathophysiological process that occurs during the liver resection and transplantation …

miRNA‑21 promotes the progression of acute liver failure via the KLF6/autophagy/IL‑23 signaling pathway

S Bao, W Zheng, R Yan, J Xu - Molecular Medicine …, 2024 - spandidos-publications.com
Acute liver failure (ALF) is a complex syndrome characterized by overactivation of innate
immunity, and the recruitment and differentiation of immune cells at inflammatory sites. The …

Skimmianine attenuates liver ischemia/reperfusion injury by regulating PI3K–AKT signaling pathway-mediated inflammation, apoptosis and oxidative stress

C Huo, B Wang, X Zhang, ZG Sun - Scientific Reports, 2023 - nature.com
Liver ischemia/reperfusion (I/R) injury is a common injury after liver transplantation and
hepatectomy. Skimmianine (Ski) has antibacterial, antiviral pharmacological effects …

KLF6 in Pulmonary Hypertension: The Dual Role of Friend and Foe

R Alharbi, N Fernandes, H Maude, A Fellows… - bioRxiv, 2024 - biorxiv.org
Background: Pulmonary arterial hypertension (PAH) is a severe lung condition with an
unmet clinical need. Endothelial damage is followed by excessive repair and narrowing of …

KLF6 aggravates myocardial fibrosis by promoting mitochondrial division.

T Zhang, H Ge, Q Song, G Yang… - Pakistan Journal of …, 2024 - search.ebscohost.com
The dysregulation of mitochondrial dynamics in cardiac fibroblasts (CFs) is closely linked to
myocardial fibrosis, which can induce cardiac dysfunction and even lead to heart failure. As …