Neurons in the hypothalamic arcuate nucleus (ARC) that express agouti‐related peptide
(AgRP) govern a critical aspect of survival: the drive to eat. Equally important to survival is …

The chronic character of chemogenetics has been put forward as one of the assets of the
technique, particularly in comparison to optogenetics. Yet, the vast majority of chemogenetic …

Autophagy represents a key regulator of aging and metabolism in sensing energy
deprivation. We find that fasting in mice activates autophagy in the liver paralleled by …

Hypothalamic gliosis associated with high-fat diet (HFD) feeding increases susceptibility to
hyperphagia and weight gain. However, the body-weight-independent contribution of …

Obesity and other eating disorders are marked by dysregulations to brain metabolic,
hedonic, motivational, and sensory systems that control food intake. Classic approaches in …

Pain chronicity involves unpleasant experience in both somatosensory and affective
aspects, accompanied with the prefrontal cortex (PFC) neuroplastic alterations. However …

In addition to their role in promoting feeding and obesity development, hypothalamic arcuate
agouti-related protein/neuropeptide Y (AgRP/NPY) neurons are widely perceived to be …

Interoceptive signals from gut and adipose tissue and sensory cues from the environment
are integrated by hubs in the brain to regulate feeding behavior and maintain homeostatic …

Dopamine acts on neurons in the arcuate nucleus (ARC) of the hypothalamus, which
controls homeostatic feeding responses. Here we demonstrate a differential enrichment of …

Abstract Agouti-related peptide (AgRP)-expressing and proopiomelanocortin (POMC)-
expressing neurons reciprocally regulate food intake. Here, we combine non-interacting …