Since no approved therapies to restore mobility and sensation following spinal cord injury
(SCI) currently exist, a better understanding of the cellular and molecular mechanisms …

Spinal cord injury is currently incurable and treatment is limited to minimising secondary
complications and maximising residual function by rehabilitation. Improved understanding of …

Spinal cord injury (SCI) is a devastating injury that characterized by oxidative stress and
inflammatory response. Kaempferol is reported to be an anti-neuroinflammation in …

Chondroitin sulphate proteoglycans in the extracellular matrix restrict plasticity in the adult
central nervous system and their digestion with chondroitinase reactivates plasticity …

Perineuronal nets (PNNs) are reticular structures that surround the cell body of many
neurones, and extend along their dendrites. They are considered to be a specialized …

Chondroitin sulphate proteoglycans (CSPGs) are potent inhibitors of growth in the adult
CNS. Use of the enzyme chondroitinase ABC (ChABC) as a strategy to reduce CSPG …

Chondroitin sulfate proteoglycans (CSPGs) inhibit repair following spinal cord injury. Here
we use mammalian-compatible engineered chondroitinase ABC (ChABC) delivered via …

Abstract Chondroitin Sulfate Proteoglycans (CSPGs) are a major component of the
extracellular matrix in the central nervous system (CNS) and play critical role in the …

Astrocytes are a major constituent of the central nervous system. These glia play a major
role in regulating blood-brain barrier function, the formation and maintenance of synapses …

Chondroitinase ABC (ChABC) in combination with rehabilitation has been shown to promote
functional recovery in acute spinal cord injury. For clinical use, the optimal treatment window …