The biology of NKT cells
A Bendelac, PB Savage, L Teyton - Annu. Rev. Immunol., 2007 - annualreviews.org
Recognized more than a decade ago, NKT cells differentiate from mainstream thymic
precursors through instructive signals emanating during TCR engagement by CD1d …
precursors through instructive signals emanating during TCR engagement by CD1d …
Hydrophobicity: an ancient damage-associated molecular pattern that initiates innate immune responses
SY Seong, P Matzinger - Nature Reviews Immunology, 2004 - nature.com
It is currently thought that immune responses are initiated by pathogen-associated molecular
patterns or by tissue-derived danger/alarm signals. Here, we propose that these two groups …
patterns or by tissue-derived danger/alarm signals. Here, we propose that these two groups …
Toward an understanding of NKT cell biology: progress and paradoxes
M Kronenberg - Annu. Rev. Immunol., 2005 - annualreviews.org
▪ Abstract Natural killer T (NKT) cells constitute a conserved T cell sublineage with unique
properties, including reactivity for a synthetic glycolipid presented by CD1d, expression of an …
properties, including reactivity for a synthetic glycolipid presented by CD1d, expression of an …
Lysosomal glycosphingolipid recognition by NKT cells
D Zhou, J Mattner, C Cantu III, N Schrantz, N Yin… - Science, 2004 - science.org
NKT cells represent a distinct lineage of T cells that coexpress a conserved αβ T cell
receptor (TCR) and natural killer (NK) receptors. Although the TCR of NKT cells is …
receptor (TCR) and natural killer (NK) receptors. Although the TCR of NKT cells is …
Biology of CD1-and MR1-restricted T cells
M Salio, JD Silk, E Yvonne Jones… - Annual review of …, 2014 - annualreviews.org
Over the past 15 years, investigators have shown that T lymphocytes can recognize not only
peptides in the context of MHC class I and class II molecules but also foreign and self-lipids …
peptides in the context of MHC class I and class II molecules but also foreign and self-lipids …
Principles of lysosomal membrane digestion: stimulation of sphingolipid degradation by sphingolipid activator proteins and anionic lysosomal lipids
T Kolter, K Sandhoff - Annu. Rev. Cell Dev. Biol., 2005 - annualreviews.org
Sphingolipids and glycosphingolipids are membrane components of eukaryotic cell
surfaces. Their constitutive degradation takes place on the surface of intra-endosomal and …
surfaces. Their constitutive degradation takes place on the surface of intra-endosomal and …
[HTML][HTML] Multiple functions of microsomal triglyceride transfer protein
Microsomal triglyceride transfer protein (MTP) was first identified as a major cellular protein
capable of transferring neutral lipids between membrane vesicles. Its role as an essential …
capable of transferring neutral lipids between membrane vesicles. Its role as an essential …
[HTML][HTML] The identification of the endogenous ligands of natural killer T cells reveals the presence of mammalian α-linked glycosylceramides
L Kain, B Webb, BL Anderson, S Deng, M Holt… - Immunity, 2014 - cell.com
Glycosylceramides in mammalian species are thought to be present in the form of β-
anomers. This conclusion was reinforced by the identification of only one glucosylceramide …
anomers. This conclusion was reinforced by the identification of only one glucosylceramide …
The lysosomal cysteine proteases in MHC class II antigen presentation
LC Hsing, AY Rudensky - Immunological reviews, 2005 - Wiley Online Library
The endosomal pathway of antigen presentation leads to the display of peptides on major
histocompatibility complex (MHC) class II molecules at the cell surface of antigen‐presenting …
histocompatibility complex (MHC) class II molecules at the cell surface of antigen‐presenting …
CD1 antigen presentation: how it works
DC Barral, MB Brenner - Nature Reviews Immunology, 2007 - nature.com
The classic concept of self–non-self discrimination by the immune system focused on the
recognition of fragments from proteins presented by classical MHC molecules. However, the …
recognition of fragments from proteins presented by classical MHC molecules. However, the …