Human diseases caused by alterations in the metabolism of sphingolipids or
glycosphingolipids are mainly disorders of the degradation of these compounds. The …

NKT cells are a relatively newly recognized member of the immune community, with
profound effects on the rest of the immune system despite their small numbers. They are true …

The glycolipid α-galactosylceramide binds with high affinity to CD1d and stimulates natural
killer T cells. Here we report the crystal structure of human CD1d in complex with synthetic α …

Cellular membranes enter the lysosomal compartment by endocytosis, phagocytosis, or
autophagy. Within the lysosomal compartment, membrane components of complex structure …

A form of α-galactosylceramide, KRN7000, activates CD1d-restricted Vα14-invariant (Vα14i)
natural killer (NK) T cells and initiates multiple downstream immune reactions. We report that …

Natural killer T (NKT) cells are innate-like lymphocytes that generally recognize lipid
antigens and are enriched in microvascular compartments of the liver. NKT cells can be …

CD1d-dependent natural killer T (NKT) cells are a unique T-cell subset with the ability to
regulate the immune system in response to a broad range of diseases. That low NKT-cell …

The discovery of molecules capable of presenting lipid antigens, the CD1 family, and of the
T cells that recognize them, has opened a new dimensionin our understanding of cell …

CD1-and MHC-related molecule-1 (MR1)-restricted T lymphocytes recognize nonpeptidic
antigens, such as lipids and small metabolites, and account for a major fraction of circulating …

Natural killer T cells express a conserved, semi-invariant αβ T cell receptor that has
specificity for self glycosphingolipids and microbial cell wall α-glycuronosylceramide …