Neonatal opioid toxicity: Opioid withdrawal (abstinence) syndrome with emphasis on pharmacogenomics and respiratory depression

BA Baldo - Archives of Toxicology, 2023 - Springer
The increasing use of opioids in pregnant women has led to an alarming rise in the number
of cases of neonates with drug-induced withdrawal symptoms known as neonatal opioid …

Effects of prenatal opioid exposure on synaptic adaptations and behaviors across development

SC Simmons, GG Grecco, BK Atwood, FS Nugent - Neuropharmacology, 2023 - Elsevier
In this review, we focus on prenatal opioid exposure (POE) given the significant concern for
the mental health outcomes of children with parents affected by opioid use disorder (OUD) in …

Prenatal morphine exposure increases cardiovascular disease risk and programs neurogenic hypertension in the adult offspring

N Ahmed, A Kassis, J Malone, J Yang, E Zamzami… - …, 2023 - Am Heart Assoc
Background: The opioid overdose and opioid use disorder epidemics are concomitant with
increased metabolic and CVD risk. Although opioid use disorder causes adverse pregnancy …

Potential problems and solutions of opioid-based treatment in neonatal opioid withdrawal syndrome (NOWS): a scoping review protocol

S Mills-Huffnagle, JE Nyland - BMJ open, 2023 - bmjopen.bmj.com
Introduction Rates of neonatal opioid withdrawal syndrome (NOWS) have paralleled the rise
of opioid use during pregnancy. While short-term phenotypic symptoms of NOWS are well …

[HTML][HTML] In utero and post-natal opioid exposure followed by mild traumatic brain injury contributes to cortical neuroinflammation, mitochondrial dysfunction, and …

AM Gowen, J Yi, K Stauch, L Miles, S Srinivasan… - Brain, Behavior, & …, 2023 - Elsevier
Maternal opioid use poses a significant health concern not just to the expectant mother but
also to the fetus. Notably, increasing numbers of children born suffering from neonatal opioid …

[HTML][HTML] Advances in animal models of prenatal opioid exposure

JR Ferrante, JA Blendy - Trends in Neurosciences, 2024 - cell.com
Neonatal opioid withdrawal syndrome (NOWS) is a growing public health concern. The
complexity of in utero opioid exposure in clinical studies makes it difficult to investigate …

[HTML][HTML] Modulation of intestinal TLR4 expression in infants with neonatal opioid withdrawal syndrome

RC Barnett, AN Lewis, Q Gong, DL Preston… - Journal of …, 2023 - nature.com
Abstract Objective Neonatal Opioid Withdrawal Syndrome (NOWS) has been associated
with the development of necrotizing enterocolitis (NEC) in term and late-preterm neonates …

Priorities for well child care of families affected by parental opioid use disorder

NK Goyal, E Sood, MA Gannon, G Harris… - Journal of Addiction …, 2023 - journals.lww.com
Methods This study is a qualitative study of parenting women from one urban, academic
OUD treatment program and pediatric primary care clinicians from a nearby affiliated …

[HTML][HTML] Molecular and long-term behavioral consequences of neonatal opioid exposure and withdrawal in mice

AD Dunn, SA Robinson, C Nwokafor, M Estill… - Frontiers in Behavioral …, 2023 - frontiersin.org
Introduction: Infants exposed to opioids in utero are at high risk of exhibiting Neonatal Opioid
Withdrawal Syndrome (NOWS), a combination of somatic withdrawal symptoms including …

Digital health interventions to support women with opioid use disorder: A scoping review

MK Ward, C Guille, A Jafry, T Gwanzura, K Pryce… - Drug and Alcohol …, 2024 - Elsevier
Background Digital health interventions have the potential to address barriers to care for
women. To design effective digital health interventions that meet the needs of this …