GPR84 is an inflammation-induced receptor highly expressed on immune cells, yet its
endogenous ligand is still unknown. This makes any interpretation of its physiological …

Idiopathic pulmonary fibrosis (IPF) is the most common fibrotic form of idiopathic diffuse lung
disease. Due to limited treatment options, IPF patients suffer from poor survival. About ten …

GPR84 is an orphan class AG protein-coupled receptor (GPCR) that is predominantly
expressed in immune cells and plays important roles in inflammation, fibrosis, and …

Altered circulating levels of free fatty acids (FFAs), namely short chain fatty acids (SCFAs),
medium chain fatty acids (MCFAs), and long chain fatty acids (LCFAs), are associated with …

Biased signaling gives hormones, probes or drugs distinct functional outcomes via the same
receptor. The Biased Signaling Atlas (https://BiasedSignalingAtlas. org) provides a …

Abstract Medium-chain triglycerides (MCTs), which consist of medium-chain fatty acids
(MCFAs), are unique forms of dietary fat with various health benefits. G protein–coupled 84 …

GPR84 is a proinflammatory G protein-coupled receptor associated with several
inflammatory and fibrotic diseases. GPR84 antagonists have been evaluated in clinical trials …

Despite the importance of members of the GPCR superfamily as targets of a broad range of
effective medicines many GPCRs remain poorly characterised. GPR84 is an example …

Since the discovery of medium-chain fatty acids as GPR84 ligands, significant
advancements have been made in the development of GPR84 agonists and antagonists …

Myeloid-derived suppressor cells (MDSCs) were found to gradually accumulate in the
orthotopic esophageal cancer mouse model during tumor progression. Although the roles of …