[HTML][HTML] Signaling pathways and targeted therapy for myocardial infarction
Q Zhang, L Wang, S Wang, H Cheng, L Xu… - Signal transduction and …, 2022 - nature.com
Although the treatment of myocardial infarction (MI) has improved considerably, it is still a
worldwide disease with high morbidity and high mortality. Whilst there is still a long way to …
worldwide disease with high morbidity and high mortality. Whilst there is still a long way to …
[HTML][HTML] Uric acid in inflammation and the pathogenesis of atherosclerosis
Y Kimura, D Tsukui, H Kono - International journal of molecular sciences, 2021 - mdpi.com
Hyperuricemia is a common metabolic syndrome. Elevated uric acid levels are risk factors
for gout, hypertension, and chronic kidney diseases. Furthermore, various epidemiological …
for gout, hypertension, and chronic kidney diseases. Furthermore, various epidemiological …
ERK1/2 MAP kinases: structure, function, and regulation
R Roskoski Jr - Pharmacological research, 2012 - Elsevier
ERK1 and ERK2 are related protein-serine/threonine kinases that participate in the Ras-Raf-
MEK-ERK signal transduction cascade. This cascade participates in the regulation of a large …
MEK-ERK signal transduction cascade. This cascade participates in the regulation of a large …
[HTML][HTML] FGF23 induces left ventricular hypertrophy
Chronic kidney disease (CKD) is a public health epidemic that increases risk of death due to
cardiovascular disease. Left ventricular hypertrophy (LVH) is an important mechanism of …
cardiovascular disease. Left ventricular hypertrophy (LVH) is an important mechanism of …
[HTML][HTML] Molecularly targeted nanomedicine enabled by inorganic nanoparticles for atherosclerosis diagnosis and treatment
Atherosclerosis, a chronic cardiovascular disease caused by plaque development in
arteries, remains a leading cause of morbidity and mortality. Atherosclerotic plaques are …
arteries, remains a leading cause of morbidity and mortality. Atherosclerotic plaques are …
Molecular distinction between physiological and pathological cardiac hypertrophy: experimental findings and therapeutic strategies
Cardiac hypertrophy can be defined as an increase in heart mass. Pathological cardiac
hypertrophy (heart growth that occurs in settings of disease, eg hypertension) is a key risk …
hypertrophy (heart growth that occurs in settings of disease, eg hypertension) is a key risk …
[PDF][PDF] Physiological role of reactive oxygen species as promoters of natural defenses
J Roy, JM Galano, T Durand, JY Le Guennec… - FASEB …, 2017 - hal.umontpellier.fr
It has been 60 yr since the discovery of reactive oxygen species (ROS) in biology and the
beginning of the scientific community's attempt to understand the impact of the unpaired …
beginning of the scientific community's attempt to understand the impact of the unpaired …
How ERK1/2 activation controls cell proliferation and cell death: Is subcellular localization the answer?
Y Mebratu, Y Tesfaigzi - Cell cycle, 2009 - Taylor & Francis
Extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) are members of the mitogen-
activated protein kinase super family that can mediate cell proliferation and apoptosis. The …
activated protein kinase super family that can mediate cell proliferation and apoptosis. The …
[HTML][HTML] Angiotensin II type I receptor (AT1R): the gate towards COVID-19-associated diseases
G El-Arif, S Khazaal, A Farhat, J Harb, C Annweiler… - Molecules, 2022 - mdpi.com
The binding of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike
glycoprotein to its cellular receptor, the angiotensin-converting enzyme 2 (ACE2), causes its …
glycoprotein to its cellular receptor, the angiotensin-converting enzyme 2 (ACE2), causes its …
p38MAPK: stress responses from molecular mechanisms to therapeutics
LR Coulthard, DE White, DL Jones… - Trends in molecular …, 2009 - cell.com
The p38 MAPK protein kinases affect a variety of intracellular responses, with well-
recognized roles in inflammation, cell-cycle regulation, cell death, development …
recognized roles in inflammation, cell-cycle regulation, cell death, development …