The clinical behaviour and outcomes of patients with oropharyngeal cancer (OPC) may be
dichotomised according to their association with human papilloma virus (HPV) infection …

The concept and realization of targeted anticancer therapy (TAT) have existed for at least
two decades and continue to expand rapidly. It has become clear that there is no “magic …

Precision medicine is a new strategy that aims at preventing and treating human diseases
by focusing on individual variations in people's genes, environment and lifestyle. Precision …

Background Platinum-based chemotherapy associated with cetuximab is the first-line
treatment for inoperable recurrence or metastatic head and neck squamous cell carcinoma …

Therapeutic strategies for advanced head and neck squamous carcinoma (HNSCC) consist
of multimodal treatment, including Epidermal Growth Factor Receptor (EGFR) inhibition …

There is no established biomarker for cetuximab efficacy in recurrent head and neck
squamous cell carcinoma (HNSCC). The aim of the present study was to evaluate the …

Objective Molecular alterations in downstream effectors of epidermal growth factor receptor
may confer resistance to epidermal growth factor receptor inhibitors. Our aim is to investigate …

Background The purpose of this phase II trial was to evaluate the tolerability, safety, and
efficacy of a non–5‐fluorouracil (5‐FU)‐based induction chemotherapy followed by …

There is a lack of studies on somatic gene mutations and cell signaling driving penile
carcinogenesis. Our objective was to analyze somatic mutations in genes downstream of …

Hyalinizing clear cell carcinoma (HCCC) is a rare, low-grade neoplasm accounting for
approximately 1% of salivary gland neoplasms. Histologically, it is characterized by a …