The group of proton-sensing G-protein coupled receptors (GPCRs) consists of the four
receptors GPR4, TDAG8 (GPR65), OGR1 (GPR68), and G2A (GPR132). These receptors …

Trigeminal neuralgia (TN) is a severe facial pain disease of unknown cause and unclear
genetic background. To examine the existing knowledge about genetics in TN, we …

Neuropathic pain is a major health problem that affects up to 7–10% of the population
worldwide. Currently, neuropathic pain is difficult to treat because of its elusive mechanisms …

Abstract Background 2, 2′-Methylenebis (4-methyl-6-tert-butylphenol)(AO2246) is a
synthetic phenolic antioxidant extensively used in food packaging bags and cosmetics …

Histone lysine crotonylation (KCR), a novel epigenetic modification, is important in
regulating a broad spectrum of biological processes and various diseases. However …

Trigeminal neuralgia (TN) is a type of severe paroxysmal neuropathic pain commonly
triggered by mild mechanical stimulation in the orofacial area. Piezo2, a mechanically gated …

Bone cancer pain (BCP) is a pervasive clinical symptom which impairs the quality life. Long
noncoding RNAs (lncRNAs) are enriched in the central nervous system and play …

Trigeminal neuropathic pain (TNP) arises due to peripheral nerve injury, the mechanisms
underlying which are little known. The altered gene expression profile in sensory ganglia is …

Background Recent studies have demonstrated the contribution of non-coding RNAs
(ncRNAs) to neuropathic pain. However, the expression profile of ncRNAs in the trigeminal …

Background Chemokine-mediated neuroinflammation plays an important role in the
pathogenesis of neuropathic pain. The chemokine CC motif ligand 7 (CCL7) and its receptor …