Intermittent metabolic switching, neuroplasticity and brain health
MP Mattson, K Moehl, N Ghena… - Nature Reviews …, 2018 - nature.com
During evolution, individuals whose brains and bodies functioned well in a fasted state were
successful in acquiring food, enabling their survival and reproduction. With fasting and …
successful in acquiring food, enabling their survival and reproduction. With fasting and …
Exercise attenuates the major hallmarks of aging
N Garatachea, H Pareja-Galeano… - Rejuvenation …, 2015 - liebertpub.com
Regular exercise has multi-system anti-aging effects. Here we summarize how exercise
impacts the major hallmarks of aging. We propose that, besides searching for novel …
impacts the major hallmarks of aging. We propose that, besides searching for novel …
Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis
Introduction Microglia are tissue macrophages of the central nervous system that monitor
brain homeostasis and react upon neuronal damage and stress. Aging and …
brain homeostasis and react upon neuronal damage and stress. Aging and …
The role of Insulin-Like Growth Factor 1 (IGF-1) in brain development, maturation and neuroplasticity
Abstract Insulin-Like Growth Factor 1 (IGF-1) is a phylogenetically ancient neurotrophic
hormone with crucial roles to play in CNS development and maturation. Recently, IGF-1 has …
hormone with crucial roles to play in CNS development and maturation. Recently, IGF-1 has …
Microglial physiology and pathophysiology: insights from genome-wide transcriptional profiling
A Crotti, RM Ransohoff - Immunity, 2016 - cell.com
Microglia originate from erythromyeloid progenitors (EMPs) in the yolk sac and develop in
the forming CNS. Microglia are fundamental for the development and function of a healthy …
the forming CNS. Microglia are fundamental for the development and function of a healthy …
The aerobic and cognitive exercise study (ACES) for community-dwelling older adults with or at-risk for mild cognitive impairment (MCI): neuropsychological …
C Anderson-Hanley, NM Barcelos… - Frontiers in aging …, 2018 - frontiersin.org
Prior research has found that cognitive benefits of physical exercise and brain health in
older adults may be enhanced when mental exercise is interactive simultaneously, as in …
older adults may be enhanced when mental exercise is interactive simultaneously, as in …
Disrupted energy metabolism and neuronal circuit dysfunction in cognitive impairment and Alzheimer's disease
D Kapogiannis, MP Mattson - The Lancet Neurology, 2011 - thelancet.com
Epidemiological, neuropathological, and functional neuroimaging evidence implicates
global and regional disruptions in brain metabolism and energetics in the pathogenesis of …
global and regional disruptions in brain metabolism and energetics in the pathogenesis of …
Adult neural stem cells bridge their niche
LC Fuentealba, K Obernier, A Alvarez-Buylla - Cell stem cell, 2012 - cell.com
Major developments in the neural stem cell (NSC) field in recent years provide new insights
into the nature of the NSC niche. In this perspective, we integrate recent anatomical data on …
into the nature of the NSC niche. In this perspective, we integrate recent anatomical data on …
Somatotropic signaling: trade-offs between growth, reproductive development, and longevity
A Bartke, LY Sun, V Longo - Physiological reviews, 2013 - journals.physiology.org
Growth hormone (GH) is a key determinant of postnatal growth and plays an important role
in the control of metabolism and body composition. Surprisingly, deficiency in GH signaling …
in the control of metabolism and body composition. Surprisingly, deficiency in GH signaling …
Effects of intermittent fasting on brain metabolism
A Brocchi, E Rebelos, A Dardano, M Mantuano… - Nutrients, 2022 - mdpi.com
We are facing an obesity epidemic, and obesity itself and its close companion, type 2
diabetes, are independent risk factors for neurodegeneration. While most medical …
diabetes, are independent risk factors for neurodegeneration. While most medical …