Targeting Nrf2 signaling pathway and oxidative stress by resveratrol for Parkinson's disease: an overview and update on new developments

MY Zamanian, RMR Parra, A Soltani… - Molecular Biology …, 2023 - Springer
Parkinson's disease (PD) as a prevalent neurodegenerative condition impairs motor function
and is caused by the progressive deterioration of nigrostriatal dopaminergic (DAergic) …

Neuroprotective properties of 4-aminopyridine

M Dietrich, HP Hartung, P Albrecht - Neurology: Neuroimmunology …, 2021 - AAN Enterprises
As an antagonist of voltage-gated potassium (Kv) channels, 4-aminopyridine (4-AP) is used
as symptomatic therapy in several neurologic disorders. The improvement of visual function …

Pyridoxine-resveratrol hybrids as novel inhibitors of MAO-B with antioxidant and neuroprotective activities for the treatment of Parkinson's disease

W Li, X Yang, Q Song, Z Cao, Y Shi, Y Deng… - Bioorganic chemistry, 2020 - Elsevier
A series of pyridoxine-resveratrol hybrids were designed and synthesized as monoamine
oxidase B inhibitors for the treatment of Parkinson's disease. Most of them exhibited potent …

[HTML][HTML] Diluted aqueous dispersed systems of 4-aminopyridine: The relationship of self-organization, physicochemical properties, and influence on the electrical …

I Ryzhkina, L Murtazina, K Gainutdinov… - Frontiers in …, 2021 - frontiersin.org
A variety of physicochemical methods were used to examine the self-organization,
physicochemical, UV absorption, and fluorescent properties of diluted aqueous solutions …

Potassium channels and their emerging role in parkinson's disease

L Zhang, Y Zheng, J Xie, L Shi - Brain research bulletin, 2020 - Elsevier
Parkinson's disease (PD) is the second most common neurodegenerative disorder, which is
associated with a selective loss of dopaminergic neurons in the substantia nigra (SN) and a …

[HTML][HTML] Current approaches and tools used in drug development against parkinson's disease

O Koszła, P Stępnicki, A Zięba, A Grudzińska… - Biomolecules, 2021 - mdpi.com
Parkinson's disease is a progressive neurodegenerative disorder characterized by the death
of nerve cells in the substantia nigra of the brain. The treatment options for this disease are …

Electron density, charge transfer, solvent effect and molecular spectroscopic studies on 2, 2-Dimethyl-N-pyridin-4-yl-propionamide–A potential antioxidant

M Sumithra, N Sundaraganesan, R Rajesh… - Computational and …, 2023 - Elsevier
Quantum-level theoretical studies employing density functional theory and spectral methods
such as Fourier Transform-Raman, Fourier Transform-Infrared, and Ultraviolet–Visible have …

Design, synthesis and biological evaluation of 3-piperazinecarboxylate sarsasapogenin derivatives as potential multifunctional anti-Alzheimer agents

GX Yang, SL Ge, Y Wu, J Huang, SL Li, R Wang… - European Journal of …, 2018 - Elsevier
A series of multifunctional 3-piperazinecarboxylate sarsasapogenin derivatives were
designed and synthesized against Alzheimer's disease (AD). The protection against H 2 O 2 …

Synthesis, X-ray crystal structure, Hirshfeld surface analysis, DFT, AIM, ELF, RDG and molecular docking studies of bis [4-(dimethylamino) pyridinium] di-µ-chlorido-bis …

M Harzallah, M Medimagh, N Issaoui… - Journal of …, 2022 - Taylor & Francis
Abstract Bis [4-(dimethylamino) pyridinium] di-µ-chlorido-bis [dichloridomercurate (II)] has
been achieved from a mixture of mercury (II) chloride in water with an aqueous HCl solution …

An Update of Synthetic Approaches and Structure‐Activity Relationships of Various Classes of Human MAO‐B Inhibitors

P Sharma, M Singh, B Mathew - ChemistrySelect, 2021 - Wiley Online Library
The selective MAO‐B inhibition is greatly influenced by the degradation pathways of various
biogenic amines. So the design and development of diverse class of MAO‐B inhibitors are …