Targeting Nrf2 signaling pathway and oxidative stress by resveratrol for Parkinson's disease: an overview and update on new developments
Parkinson's disease (PD) as a prevalent neurodegenerative condition impairs motor function
and is caused by the progressive deterioration of nigrostriatal dopaminergic (DAergic) …
and is caused by the progressive deterioration of nigrostriatal dopaminergic (DAergic) …
Neuroprotective properties of 4-aminopyridine
M Dietrich, HP Hartung, P Albrecht - Neurology: Neuroimmunology …, 2021 - AAN Enterprises
As an antagonist of voltage-gated potassium (Kv) channels, 4-aminopyridine (4-AP) is used
as symptomatic therapy in several neurologic disorders. The improvement of visual function …
as symptomatic therapy in several neurologic disorders. The improvement of visual function …
Pyridoxine-resveratrol hybrids as novel inhibitors of MAO-B with antioxidant and neuroprotective activities for the treatment of Parkinson's disease
W Li, X Yang, Q Song, Z Cao, Y Shi, Y Deng… - Bioorganic chemistry, 2020 - Elsevier
A series of pyridoxine-resveratrol hybrids were designed and synthesized as monoamine
oxidase B inhibitors for the treatment of Parkinson's disease. Most of them exhibited potent …
oxidase B inhibitors for the treatment of Parkinson's disease. Most of them exhibited potent …
[HTML][HTML] Diluted aqueous dispersed systems of 4-aminopyridine: The relationship of self-organization, physicochemical properties, and influence on the electrical …
I Ryzhkina, L Murtazina, K Gainutdinov… - Frontiers in …, 2021 - frontiersin.org
A variety of physicochemical methods were used to examine the self-organization,
physicochemical, UV absorption, and fluorescent properties of diluted aqueous solutions …
physicochemical, UV absorption, and fluorescent properties of diluted aqueous solutions …
Potassium channels and their emerging role in parkinson's disease
L Zhang, Y Zheng, J Xie, L Shi - Brain research bulletin, 2020 - Elsevier
Parkinson's disease (PD) is the second most common neurodegenerative disorder, which is
associated with a selective loss of dopaminergic neurons in the substantia nigra (SN) and a …
associated with a selective loss of dopaminergic neurons in the substantia nigra (SN) and a …
[HTML][HTML] Current approaches and tools used in drug development against parkinson's disease
O Koszła, P Stępnicki, A Zięba, A Grudzińska… - Biomolecules, 2021 - mdpi.com
Parkinson's disease is a progressive neurodegenerative disorder characterized by the death
of nerve cells in the substantia nigra of the brain. The treatment options for this disease are …
of nerve cells in the substantia nigra of the brain. The treatment options for this disease are …
Electron density, charge transfer, solvent effect and molecular spectroscopic studies on 2, 2-Dimethyl-N-pyridin-4-yl-propionamide–A potential antioxidant
M Sumithra, N Sundaraganesan, R Rajesh… - Computational and …, 2023 - Elsevier
Quantum-level theoretical studies employing density functional theory and spectral methods
such as Fourier Transform-Raman, Fourier Transform-Infrared, and Ultraviolet–Visible have …
such as Fourier Transform-Raman, Fourier Transform-Infrared, and Ultraviolet–Visible have …
Design, synthesis and biological evaluation of 3-piperazinecarboxylate sarsasapogenin derivatives as potential multifunctional anti-Alzheimer agents
GX Yang, SL Ge, Y Wu, J Huang, SL Li, R Wang… - European Journal of …, 2018 - Elsevier
A series of multifunctional 3-piperazinecarboxylate sarsasapogenin derivatives were
designed and synthesized against Alzheimer's disease (AD). The protection against H 2 O 2 …
designed and synthesized against Alzheimer's disease (AD). The protection against H 2 O 2 …
Synthesis, X-ray crystal structure, Hirshfeld surface analysis, DFT, AIM, ELF, RDG and molecular docking studies of bis [4-(dimethylamino) pyridinium] di-µ-chlorido-bis …
M Harzallah, M Medimagh, N Issaoui… - Journal of …, 2022 - Taylor & Francis
Abstract Bis [4-(dimethylamino) pyridinium] di-µ-chlorido-bis [dichloridomercurate (II)] has
been achieved from a mixture of mercury (II) chloride in water with an aqueous HCl solution …
been achieved from a mixture of mercury (II) chloride in water with an aqueous HCl solution …
An Update of Synthetic Approaches and Structure‐Activity Relationships of Various Classes of Human MAO‐B Inhibitors
The selective MAO‐B inhibition is greatly influenced by the degradation pathways of various
biogenic amines. So the design and development of diverse class of MAO‐B inhibitors are …
biogenic amines. So the design and development of diverse class of MAO‐B inhibitors are …