Death by suicide is a global epidemic with over 800 K suicidal deaths worlwide in 2012.
Suicide is the 10th leading cause of death among Americans and more than 44 K people …

Endometriosis (EM), defined as the presence of endometrial-like tissue with surrounding
smooth muscle cells outside the uterus, is a disregarded gynecological disease reported to …

Abstract Development of newer synthetic methodologies to access medium ring–sized
heterocyclic compounds is an important current activity, partly because of the biological and …

Opioid receptors may play critical roles in alcoholism and other addictions, addiction
withdrawal, and depression and are considered pharmacological targets for treatment of …

Drug addiction is a complex, persistent, and chronically relapsing neurological disorder
exacerbated by acute and chronic stress. It is well known that the dynorphin/kappa opioid …

Rationale Kappa-opioid receptor (KOR) agonists are antinociceptive but have side effects
that limit their therapeutic utility. New KOR agonists have been developed that are fully …

Objective: Drug-induced hypoglycaemia has been described with the use of tramadol and
methadone. The authors aimed to determine if drug-induced hypoglycaemia could be a …

Social stressors are known to have strong negative impacts on mental health. There is a
long history of preclinical social defeat stress studies in rodents focusing on males that has …

This chapter provides a general introduction to the dynorphins (DYNs)/kappa opioid
receptor (KOR) system, including DYN peptides, neuroanatomy of the DYNs/KOR system …

Tissue injury produces a delicate balance between latent pain sensitization (LS) and
compensatory endogenous opioid receptor analgesia that continues for months, even after …