Metformin is one of the most commonly used first-line oral medications for type 2 diabetes
mellitus. Multiple observational studies, reviewed in numerous systematic reviews, have …

Original research: Metformin increases natural killer cell functions in head and neck squamous
cell carcinoma through CXCL1 inhibition - PMC Back to Top Skip to main content NIH NLM …

The tumor microenvironment (TME) plays a pivotal role in the fate of cancer cells, and tumor-
infiltrating immune cells have emerged as key players in shaping this complex milieu …

Senescence suppresses tumor growth, while also developing a tumorigenic state in the
nearby cells that is mediated by senescence-associated secretory phenotypes (SASPs). The …

Based on high quality surgery and scientific data, scientists and surgeons are committed to
protecting patients as well as healthcare staff and hereby provide this Guidance to address …

Endometrial cancer is the most common gynecologic malignancy in developed countries. Its
increasing incidence is thought to be related in part to the rise of metabolic syndrome, which …

Tumor-infiltrated lymphocytes are exposed to many toxic metabolites and molecules in the
tumor microenvironment (TME) that suppress their anti-tumor activity. Toxic metabolites …

Purpose of review To give an overview of the current knowledge regarding the diagnosis,
treatment, and follow-up of laryngeal dysplasia (LD) and to highlight the contributions of …

Because of the heterogeneity and complexity of tumor structure, cancer drugs often cannot
effectively reach the tumor, which is one of the reasons for drug resistance and treatment …

Background Metformin is a commonly used antidiabetic medication which has demonstrated
promise as an anticancer agent alone and in combination with conventional treatment …