Objective: The 2x2 factorial design is an effective method that allows for multiple
comparisons, especially in the context of interactions between different interventions, without …

Objective In many cancers, including head and neck squamous cell carcinoma (HNSCC),
different regions within a tumor have different metabolic phenotypes. Transfer of metabolites …

Background Preclinical studies showed metformin reduces exhaustion of tumor-infiltrating
lymphocytes and potentiates programmed cell death protein-1 (PD-1) blockade. We …

Aims and Objective: The term chemoprevention denotes the use of specific natural or
synthetic chemical agents to prevent carcinogenesis. Chemoprevention may help delay the …

Objective Many aggressive head and neck cancers contain 2 metabolically coupled tumor
compartments: a glycolytic stromal compartment with low caveolin-1 (CAV1) and high …

Assessing tumour response using a traditional phase I, II and III trial approach is not without
limitations, particularly when targeted therapies are involved. Window of opportunity trials …

Head and neck cancer (HNC) is the 6th most common cancer worldwide, the majority of
which are head and neck squamous cell carcinomas (HNSCC). Recurrent or metastatic …

The vocal fold epithelium is nonkeratinized stratified squamous epithelium divided into 2
main layers, the basal layer and the suprabasal layer. Epithelial cells proliferate from the …

Background The primary purpose of this study was to investigate the significance of
pretreatment glycemic parameters in the prognosis of head and neck squamous cell …

The complex neoplastic tissue and its microenvironment often posit intratumor
heterogeneity, affecting drug molecule distribution in the tumor. A deep understanding of the …