The host immune system plays an important role in chronic hepatitis B (CHB), both in viral
clearance and hepatocellular damage. Advances in our understanding of the natural history …

Interferons (IFN) s are involved in numerous immune interactions during viral infections and
contribute to both induction and regulation of innate and adaptive antiviral mechanisms …

Hemophagocytic lymphohistiocytosis (HLH) is a rare disorder with familial and acquired
forms. The familial form is associated with mutations in the perforin gene and both forms are …

Virus-specific CD8+ T cells develop the ability to function in an “innate” capacity by
responding to a remarkable array of cytokines in a TCR-independent manner. Although …

Translation is a critical process in protein synthesis, but translational regulation in antigen-
specific T cells in vivo has not been well defined. Here we have characterized the …

Dengue virus (DEN) causes dengue fever and dengue hemorrhagic fever/dengue shock
syndrome, which are major public health problems worldwide. The immune factors that …

The newborn immune system is characterized by an impaired Th1-associated immune
response. Hepatitis B virus (HBV) transmitted from infected mothers to newborns is thought …

Autoimmune diabetes mellitus in humans is characterized by immunological destruction of
pancreatic beta islet cells. We investigated the circumstances under which CD8+ T cells …

Differentiation of dendritic cells (DCs) into particular subsets may act to shape innate and
adaptive immune responses, but little is known about how this occurs during infections …

Decay-accelerating factor (Daf) dissociates C3/C5 convertases that assemble on host cells
and thereby prevents complement activation on their surfaces. We demonstrate that during …