[HTML][HTML] The metabolic and molecular mechanisms of α‑mangostin in cardiometabolic disorders

OD John, AT Mushunje… - International …, 2022 - spandidos-publications.com
Abstract α‑mangostin is a xanthone predominantly encountered in Garcinia mangostana.
Extensive research has been carried out concerning the effects of this compound on various …

Syringaresinol protects against type 1 diabetic cardiomyopathy by alleviating inflammation responses, cardiac fibrosis, and oxidative stress

G Li, L Yang, L Feng, J Yang, Y Li, J An… - Molecular Nutrition & …, 2020 - Wiley Online Library
Scope Syringaresinol (SYR) is a phenolic compound, which could be found in various
cereals and medicinal plants. It exerts both anti‐inflammatory and antioxidant …

Omnifarious fruit polyphenols: an omnipotent strategy to prevent and intervene diabetes and related complication?

Y Chen, X Qie, W Quan, M Zeng, F Qin… - Critical Reviews in …, 2023 - Taylor & Francis
Diabetes mellitus is a metabolic syndrome which cannot be cured. Recently, considerable
interest has been focused on food ingredients to prevent and intervene in complications of …

[HTML][HTML] Effect of alpha-mangostin on olanzapine-induced metabolic disorders in rats

A Ardakanian, MG Rahbardar… - Iranian Journal of …, 2022 - ncbi.nlm.nih.gov
Objective (s): As olanzapine has side effects such as weight gain and metabolic disorders,
and alpha-mangostin has been shown to control metabolic disorders, the effects of alpha …

[HTML][HTML] Sacubitril/valsartan combination enhanced cardiac glycophagy and prevented the progression of murine diabetic cardiomyopathy

DSA Elshenawy, NM Ramadan, VB Abdo… - Biomedicine & …, 2022 - Elsevier
Background Diabetic cardiomyopathy (DCM) is linked to disturbance in cardiac glucose
handling and increased cardiac glycogen storage. This study tested the potential role of …

[HTML][HTML] α-Mangostin Inhibits the Activation of Myofibroblasts via Downregulation of Linc-ROR-Mediated TGFB1/Smad Signaling

YH Lee, PL Hsieh, SC Chao, YW Liao, CM Liu, CC Yu - Nutrients, 2023 - mdpi.com
Oral submucous fibrosis (OSF) is a premalignant disorder and persistent activation of
myofibroblasts is implicated in this pathological progression. Increasing attention has been …

Transcriptome Analysis Illuminates a Hub Role of SREBP2 in Cholesterol Metabolism by α-Mangostin

HS Chae, HJ Kim, HJ Ko, CH Lee, YH Choi… - AcS Omega, 2020 - ACS Publications
Whole-transcriptome analysis of α-mangostin-treated HepG2 cells revealed that genes
relevant to lipid and cholesterol metabolic processes responded to α-mangostin treatment. α …

Alpha-Mangosteen lessens high-fat/high-glucose diet and low-dose streptozotocin induced-hepatic manifestations in the insulin resistance rat model

V Soetikno, P Andini, M Iskandar… - Pharmaceutical …, 2023 - Taylor & Francis
Context α-Mangosteen (α-MG) attenuates insulin resistance (IR). However, it is still unknown
whether α-MG could alleviate hepatic manifestations in IR rats. Objective To investigate the …

Ameliorative effect of Metformin/alpha-lipoic acid combination on diabetic nephropathy via modulation of YAP/miR-29a/PTEN/p-AKT axis

SA Helmy, OA Nour, G Al Shaima - International Immunopharmacology, 2024 - Elsevier
Diabetic nephropathy (DN) is the most frequent and serious complication of type 2 diabetes
(T2DM). Lack of a precise remedy and socio-economic burden of DN patients implements …

Antioxidative activities of alpha-mangostin in high-fat/high-glucose diet and streptozotocin-induced insulin-resistant rodents

G Lazarus, S Alexander, GO Kusuma… - Journal of Applied …, 2020 - japsonline.com
Insulin resistance (IR), of which pathomechanism is mainly mediated by oxidative stress,
leads to impaired insulin secretion and multisystem damages. Recent evidence suggests …