Ovarian cancer is the most lethal of all gynecological malignancies, and the identification of
novel prognostic and therapeutic targets for ovarian cancer is crucial. It is believed that only …

Mitogen-activated protein kinases (MAPKs) are critical components of a complex
intracellular signalling network that ultimately regulates gene expression in response to a …

cis-Diamminedichloroplatinum (II)(cisplatin) is among the most active antitumour agent used
in human chemotherapy. The purpose of this review is to give an insight in several …

This study investigated the effects of dietary proteins on the growth, disease resistance,
intestinal immune and physical barrier functions of young grass carp (Ctenopharyngodon …

Abstract Hormone-receptor positive (HR+) breast cancer (BC)(including the luminal A and
the luminal B subtypes) is the most common type of tumor in women diagnosed with early …

Concurrent administration of radiation and chemotherapy has emerged as a dominant form
of cancer treatment. Nevertheless, our understanding of the specific mechanisms of …

DNA-alkylating agents that are platinum complexes induce apoptotic responses and have
wide application in cancer therapy. The potential for platinum compounds to modulate signal …

Cisplatin is one of the most potent anticancer agents, displaying significant clinical activity
against a variety of solid tumors. For more than two decades, the most effective systemic …

Resistance to cisplatin‐based chemotherapy is a major cause of treatment failure in human
ovarian cancer. Wild‐type TP53 status is often, but not always, associated with cisplatin …

Loss of DNA mismatch repair (MMR) in mammalian cells, as well as having a causative role
in cancer, has been linked to resistance to certain DNA damaging agents including clinically …