[HTML][HTML] Understanding the combined effects of multiple stressors: A new perspective on a longstanding challenge

E Pirotta, L Thomas, DP Costa, AJ Hall… - Science of the Total …, 2022 - Elsevier
Wildlife populations and their habitats are exposed to an expanding diversity and intensity of
stressors caused by human activities, within the broader context of natural processes and …

[HTML][HTML] An introduction to terminology and methodology of chemical synergy—perspectives from across disciplines

KR Roell, DM Reif, AA Motsinger-Reif - Frontiers in pharmacology, 2017 - frontiersin.org
The idea of synergistic interactions between drugs and chemicals has been an important
issue in the biomedical world for over a century. As complex diseases, especially cancer …

Predictive environmental risk assessment of chemical mixtures: a conceptual framework

T Backhaus, M Faust - Environmental science & technology, 2012 - ACS Publications
Environmental risks of chemicals are still often assessed substance-by-substance,
neglecting mixture effects. This may result in risk underestimations, as the typical exposure …

Mycotoxins co-contamination: Methodological aspects and biological relevance of combined toxicity studies

I Alassane-Kpembi, G Schatzmayr… - Critical Reviews in …, 2017 - Taylor & Francis
Mycotoxins are secondary fungal metabolites produced mainly by Aspergillus, Penicillium,
and Fusarium. As evidenced by large-scale surveys, humans and animals are …

[HTML][HTML] Current EU research activities on combined exposure to multiple chemicals

SK Bopp, R Barouki, W Brack, S Dalla Costa… - Environment …, 2018 - Elsevier
Humans and wildlife are exposed to an intractably large number of different combinations of
chemicals via food, water, air, consumer products, and other media and sources. This raises …

Multicomponent therapeutics for networked systems

CT Keith, AA Borisy, BR Stockwell - Nature reviews Drug discovery, 2005 - nature.com
Therapeutic regimens that comprise more than one active ingredient are commonly used in
clinical medicine. Despite this, most drug discovery efforts search for drugs that are …

[HTML][HTML] Risk assessment of environmental mixture effects

KA Heys, RF Shore, MG Pereira, KC Jones, FL Martin - RSC advances, 2016 - pubs.rsc.org
In the environment, organisms are exposed to a diverse array of chemicals in complex
mixtures. The majority of approaches that aim to assess the risk of environmental chemical …

Environmental exposure and risk assessment of fluoroquinolone antibacterial agents in wastewater and river water of the Glatt Valley Watershed, Switzerland

EM Golet, AC Alder, W Giger - Environmental science & …, 2002 - ACS Publications
The mass flows of fluoroquinolone antibacterial agents (FQs) were investigated in the
aqueous compartments of the Glatt Valley Watershed, a densely populated region in …

Modes of action in ecotoxicology: their role in body burdens, species sensitivity, QSARs, and mixture effects

BI Escher, JLM Hermens - Environmental science & technology, 2002 - ACS Publications
In contrast to the general research attitude in the basic sciences, environmental sciences are
often goal-driven and should provide the scientific basis for risk assessment procedures …

Human health implications of environmental contaminants in Arctic Canada: a review

J Van Oostdam, SG Donaldson, M Feeley… - Science of the total …, 2005 - Elsevier
The objectives of this paper are to: assess the impact of exposure to current levels of
environmental contaminants in the Canadian Arctic on human health; identify the data and …