[HTML][HTML] Understanding the combined effects of multiple stressors: A new perspective on a longstanding challenge
Wildlife populations and their habitats are exposed to an expanding diversity and intensity of
stressors caused by human activities, within the broader context of natural processes and …
stressors caused by human activities, within the broader context of natural processes and …
[HTML][HTML] An introduction to terminology and methodology of chemical synergy—perspectives from across disciplines
The idea of synergistic interactions between drugs and chemicals has been an important
issue in the biomedical world for over a century. As complex diseases, especially cancer …
issue in the biomedical world for over a century. As complex diseases, especially cancer …
Predictive environmental risk assessment of chemical mixtures: a conceptual framework
T Backhaus, M Faust - Environmental science & technology, 2012 - ACS Publications
Environmental risks of chemicals are still often assessed substance-by-substance,
neglecting mixture effects. This may result in risk underestimations, as the typical exposure …
neglecting mixture effects. This may result in risk underestimations, as the typical exposure …
Mycotoxins co-contamination: Methodological aspects and biological relevance of combined toxicity studies
I Alassane-Kpembi, G Schatzmayr… - Critical Reviews in …, 2017 - Taylor & Francis
Mycotoxins are secondary fungal metabolites produced mainly by Aspergillus, Penicillium,
and Fusarium. As evidenced by large-scale surveys, humans and animals are …
and Fusarium. As evidenced by large-scale surveys, humans and animals are …
[HTML][HTML] Current EU research activities on combined exposure to multiple chemicals
SK Bopp, R Barouki, W Brack, S Dalla Costa… - Environment …, 2018 - Elsevier
Humans and wildlife are exposed to an intractably large number of different combinations of
chemicals via food, water, air, consumer products, and other media and sources. This raises …
chemicals via food, water, air, consumer products, and other media and sources. This raises …
Multicomponent therapeutics for networked systems
CT Keith, AA Borisy, BR Stockwell - Nature reviews Drug discovery, 2005 - nature.com
Therapeutic regimens that comprise more than one active ingredient are commonly used in
clinical medicine. Despite this, most drug discovery efforts search for drugs that are …
clinical medicine. Despite this, most drug discovery efforts search for drugs that are …
[HTML][HTML] Risk assessment of environmental mixture effects
In the environment, organisms are exposed to a diverse array of chemicals in complex
mixtures. The majority of approaches that aim to assess the risk of environmental chemical …
mixtures. The majority of approaches that aim to assess the risk of environmental chemical …
Environmental exposure and risk assessment of fluoroquinolone antibacterial agents in wastewater and river water of the Glatt Valley Watershed, Switzerland
EM Golet, AC Alder, W Giger - Environmental science & …, 2002 - ACS Publications
The mass flows of fluoroquinolone antibacterial agents (FQs) were investigated in the
aqueous compartments of the Glatt Valley Watershed, a densely populated region in …
aqueous compartments of the Glatt Valley Watershed, a densely populated region in …
Modes of action in ecotoxicology: their role in body burdens, species sensitivity, QSARs, and mixture effects
BI Escher, JLM Hermens - Environmental science & technology, 2002 - ACS Publications
In contrast to the general research attitude in the basic sciences, environmental sciences are
often goal-driven and should provide the scientific basis for risk assessment procedures …
often goal-driven and should provide the scientific basis for risk assessment procedures …
Human health implications of environmental contaminants in Arctic Canada: a review
J Van Oostdam, SG Donaldson, M Feeley… - Science of the total …, 2005 - Elsevier
The objectives of this paper are to: assess the impact of exposure to current levels of
environmental contaminants in the Canadian Arctic on human health; identify the data and …
environmental contaminants in the Canadian Arctic on human health; identify the data and …