Overdose deaths are often viewed as the leading edge of the opioid epidemic which has
gripped the United States over the past two decades (Skolnick, 2018a). This emphasis is …

Fentanyl is a powerful opioid anesthetic and analgesic, the use of which has caused an
increasing public health threat in the United States and elsewhere. Fentanyl was initially …

Opioid overdose is the leading cause of death for Americans 25 to 64 years of age, and
opioid use disorder affects> 2 million Americans. The epidemiology of opioid-associated out …

The recent outbreak of SARS-CoV-2 infections that causes coronavirus-induced disease of
2019 (COVID-19) is the defining and unprecedented global health crisis of our time in both …

Dysregulation of the immune system is a cardinal feature of opioid addiction. Here, we
characterize the landscape of peripheral immune cells from patients with opioid use disorder …

Heroin is an opioid agonist commonly abused for its rewarding effects. Since its synthesis at
the end of the nineteenth century, its popularity as a recreational drug has ebbed and …

In December 2018, the Centers for Disease Control declared fentanyl the deadliest drug in
America. Opioid overdose is the single greatest cause of death in the United States adult …

Over the past three decades the United States has experienced a devastating opioid
epidemic. One of the many debilitating side effects of chronic opioid use is opioid-induced …

Opioids such as morphine—acting at the mu opioid receptor—are the mainstay for treatment
of moderate to severe pain and have good efficacy in these indications. However, these …

Oxycodone, a semisynthetic derivative of naturally occurring thebaine, an opioid alkaloid,
has been available for more than 100 years. Although thebaine cannot be used …