The co-occurrence of diseases can inform the underlying network biology of shared and
multifunctional genes and pathways. In addition, comorbidities help to elucidate the effects …

Shared aetiopathogenic factors among immune-mediated diseases have long been
suggested by their co-familiality and co-occurrence, and molecular support has been …

Inflammatory bowel disease (IBD) is associated with risk variants in the human genome and
dysbiosis of the gut microbiome, though unifying principles for these findings remain largely …

Non-additive genetic variance for complex traits is traditionally estimated from data on
relatives. It is notoriously difficult to estimate without bias in non-laboratory species …

INTRODUCTION Genetic interactions occur when mutations in different genes combine to
result in a phenotype that is different from expectation based on those of the individual …

Over the past decade, advances in both molecular developmental biology and evolutionary
ecology have made possible a new understanding of organisms as dynamic systems …

A major challenge in genetics is to identify genetic variants driving natural phenotypic
variation. However, current methods of genetic mapping have limited resolution. To address …

Abstract Systems genetics is an approach to understand the flow of biological information
that underlies complex traits. It uses a range of experimental and statistical methods to …

Adaptation in response to selection on polygenic phenotypes may occur via subtle allele
frequencies shifts at many loci. Current population genomic techniques are not well posed to …

Biological invasions constitute a major environmental change driver, affecting conservation,
agriculture and human health. Invasive alien species (IAS) impacts include, alterations of …