Orchestrating single-cell analysis with Bioconductor
Recent technological advancements have enabled the profiling of a large number of
genome-wide features in individual cells. However, single-cell data present unique …
genome-wide features in individual cells. However, single-cell data present unique …
[PDF][PDF] Review on epidermal growth factor receptor (EGFR) structure, signaling pathways, interactions, and recent updates of EGFR inhibitors
The epidermal growth factor receptor (EGFR) belongs to the ERBB family of tyrosine kinase
receptors. EGFR signaling cascade is a key regulator in cell proliferation, differentiation …
receptors. EGFR signaling cascade is a key regulator in cell proliferation, differentiation …
Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer's disease
The extent of microglial heterogeneity in humans remains a central yet poorly explored
question in light of the development of therapies targeting this cell type. Here, we investigate …
question in light of the development of therapies targeting this cell type. Here, we investigate …
The reactome pathway knowledgebase
B Jassal, L Matthews, G Viteri, C Gong… - Nucleic acids …, 2020 - academic.oup.com
Abstract The Reactome Knowledgebase (https://reactome. org) provides molecular details of
signal transduction, transport, DNA replication, metabolism and other cellular processes as …
signal transduction, transport, DNA replication, metabolism and other cellular processes as …
Whole genome, transcriptome and methylome profiling enhances actionable target discovery in high-risk pediatric cancer
Abstract The Zero Childhood Cancer Program is a precision medicine program to benefit
children with poor-outcome, rare, relapsed or refractory cancer. Using tumor and germline …
children with poor-outcome, rare, relapsed or refractory cancer. Using tumor and germline …
Pathway enrichment analysis and visualization of omics data using g: Profiler, GSEA, Cytoscape and EnrichmentMap
Pathway enrichment analysis helps researchers gain mechanistic insight into gene lists
generated from genome-scale (omics) experiments. This method identifies biological …
generated from genome-scale (omics) experiments. This method identifies biological …
STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets
Proteins and their functional interactions form the backbone of the cellular machinery. Their
connectivity network needs to be considered for the full understanding of biological …
connectivity network needs to be considered for the full understanding of biological …
MOFA+: a statistical framework for comprehensive integration of multi-modal single-cell data
Technological advances have enabled the profiling of multiple molecular layers at single-
cell resolution, assaying cells from multiple samples or conditions. Consequently, there is a …
cell resolution, assaying cells from multiple samples or conditions. Consequently, there is a …
RNA-Seq signatures normalized by mRNA abundance allow absolute deconvolution of human immune cell types
The molecular characterization of immune subsets is important for designing effective
strategies to understand and treat diseases. We characterized 29 immune cell types within …
strategies to understand and treat diseases. We characterized 29 immune cell types within …
ShinyGO: a graphical gene-set enrichment tool for animals and plants
Motivation Gene lists are routinely produced from various omic studies. Enrichment analysis
can link these gene lists with underlying molecular pathways and functional categories such …
can link these gene lists with underlying molecular pathways and functional categories such …