The vascular endothelial growth factor (VEGF) family, the regulator of blood and lymphatic
vessels, is mostly investigated in the tumor and ophthalmic field. However, the functions it …

Cancer is currently the second leading cause of death globally and is expected to be
responsible for approximately 9.6 million deaths in 2018. With an unprecedented …

Excessive abnormal angiogenesis plays a pivotal role in tumor progression and is a
hallmark of solid tumors. This process is driven by an imbalance between pro-and anti …

Tumours require a vascular supply to grow and can achieve this via the expression of pro-
angiogenic growth factors, including members of the vascular endothelial growth factor …

The vascular endothelial growth factor receptor-1 (VEGFR-1) is a tyrosine kinase receptor
for VEGF-A, VEGF-B, and placental growth factor (PlGF) ligands that is expressed in …

Significance: Proangiogenic therapy appeared a promising strategy for the treatment of
patients with acute myocardial infarction (MI), as de novo formation of microvessels, has the …

After the onset of ischemia, cardiac or skeletal muscle undergoes a continuum of molecular,
cellular, and extracellular responses that determine the function and the remodeling of the …

Heart failure is a devastating condition, the progression of which culminates in a mismatch of
oxygen supply and demand, with limited options for treatment. Heart failure has several …

Preeclampsia (PE) is a disorder occurring after week 20 of pregnancy and marked by
hypertension and proteinuria. It is the major cause of maternal and fetal morbidity worldwide …

High-grade gliomas (HGGs) are vascular tumors that represent attractive targets for
antiangiogenic therapies. In this Review, we present the rationale and clinical trial evidence …