Cardiogenesis is an exquisitely sensitive process. Any perturbation in the cells that
contribute to the building of the heart leads to cardiac malformations, which frequently result …

Different cell types, equipped with unique structure and function, synthesize different sets of
proteins on the basis of different patterns of gene expression, even though their genomes …

During the past decade, an emerging body of evidence has accumulated that cardiac
transcription factors control a cardiac gene program and play a critical role in transcriptional …

In this review we discuss the major morphogenetic and regulative events that control
myocardial progenitor cells from the time that they delaminate from the epiblast in the …

The precursors of several organs reside within the lateral plate mesoderm of vertebrate
embryos. Here, we demonstrate that the zebrafish hands off locus is essential for the …

Understanding early cardiac morphogenesis, especially the process of cardiac looping, is of
fundamental interest for diverse biomedical disciplines. During the past few years …

During the early stages of pregnancy, fertilized embryos must attach to the uterine
epithelium, invade into the underlying uterine stroma, and the stroma must then differentiate …

An intricate array of heterogeneous transcription factors participate in programming tissue-
specific gene expression through combinatorial interactions that are unique to a given cell …

A finite number of transcription factors constitute a combinatorial code that orchestrates
cardiac development and the specification and differentiation of myocytes. Many, if not all of …

The basic helix-loop-helix (bHLH) family of proteins is a group of functionally diverse
transcription factors found in both plants and animals. These proteins evolved early in …