Osteoporosis: an update on screening, diagnosis, evaluation, and treatment

SA Sabri, JC Chavarria, C Ackert-Bicknell… - …, 2023 - journals.healio.com
Osteoporosis screening, diagnosis, and treatment have gained much attention in the health
care community over the past 2 decades. During this time, creation of multispecialty …

[HTML][HTML] The role of genetic and epigenetic factors in determining the risk of spinal fragility fractures: new insights in the management of spinal osteoporosis

V Himič, N Syrmos, GKI Ligarotti, S Kato… - … Imaging in Medicine …, 2023 - ncbi.nlm.nih.gov
Osteoporosis predisposes patients to spinal fragility fractures. Imaging plays a key role in the
diagnosis and prognostication of these osteoporotic vertebral fractures (OVF). However, the …

The emerging role of MicroRNAs in bone diseases and their therapeutic potential

LA Bravo Vázquez, MY Moreno Becerril… - Molecules, 2021 - mdpi.com
MicroRNAs (miRNAs) are a class of small (20–24 nucleotides), highly conserved, non-
coding RNA molecules whose main function is the post-transcriptional regulation of gene …

Pregnancy and lactation, a challenge for the skeleton

EM Winter, A Ireland, NC Butterfield… - Endocrine …, 2020 - ec.bioscientifica.com
In this review we discuss skeletal adaptations to the demanding situation of pregnancy and
lactation. Calcium demands are increased during pregnancy and lactation, and this is …

Efficient lung-targeted delivery of risedronate sodium/vitamin D3 conjugated PAMAM-G5 dendrimers for managing osteoporosis: Pharmacodynamics, molecular …

NME Elsayyad, I Gomaa, MA Salem, R Amer… - Life sciences, 2022 - Elsevier
Aims This study aims at formulating combined delivery of Risedronate sodium (RIS) and
Vitamin D3 (VITD3) for augmented therapeutic outcome against osteoporosis (OP) using …

Semiautomated Electrochemical Melting Curve Analysis Device for the Detection of an Osteoporosis Associated Single Nucleotide Polymorphism in Blood

CP Yenice, N Chahin, M Jauset-Rubio, M Hall… - Analytical …, 2023 - ACS Publications
The detection of single nucleotide polymorphisms (SNPs) is of increasing importance in
many areas including clinical diagnostics, patient stratification for pharmacogenomics, and …

UBAP2 plays a role in bone homeostasis through the regulation of osteoblastogenesis and osteoclastogenesis

J Kim, BY Kim, JS Lee, YM Jeong, HJ Cho… - Nature …, 2023 - nature.com
Osteoporosis is a condition characterized by decreased bone mineral density (BMD) and
reduced bone strength, leading to an increased risk of fractures. Here, to identify novel risk …

A roadmap to gene discoveries and novel therapies in monogenic low and high bone mass disorders

MM Formosa, DJM Bergen, CL Gregson… - Frontiers in …, 2021 - frontiersin.org
Genetic disorders of the skeleton encompass a diverse group of bone diseases differing in
clinical characteristics, severity, incidence and molecular etiology. Of particular interest are …

Perspective of the GEMSTONE consortium on current and future approaches to functional validation for skeletal genetic disease using cellular, molecular and animal …

M Rauner, I Foessl, MM Formosa, E Kague… - Frontiers in …, 2021 - frontiersin.org
The availability of large human datasets for genome-wide association studies (GWAS) and
the advancement of sequencing technologies have boosted the identification of genetic …

WNT11, a new gene associated with early onset osteoporosis, is required for osteoblastogenesis

C Caetano da Silva, T Edouard, M Fradin… - Human Molecular …, 2022 - academic.oup.com
Monogenic early onset osteoporosis (EOOP) is a rare disease defined by low bone mineral
density (BMD) that results in increased risk of fracture in children and young adults. Although …