Sex differences are present across multiple non-reproductive organ cancers, with male
individuals generally experiencing higher incidence of cancer with poorer outcomes …

Simple Summary Colorectal cancer is a leading cause of cancer mortality, and its incidence
is rapidly increasing worldwide. Colorectal cancer is considered a single entity based on …

Deficiency of DNA repair pathways drives the development of colorectal cancer. However,
the role of the base excision repair (BER) pathway in colorectal cancer initiation remains …

Melanoma incidence and mortality rates are historically higher for men than women.
Although emerging studies have highlighted tumorigenic roles for the male sex hormone …

Background Glioblastoma (GBM) is a highly malignant brain tumor that affects men more
often than women. In addition, the former shows a poorer survival prognosis. To date, the …

Epigenetic modifications, including posttranslational modifications of histones, are closely
linked to transcriptional regulation. Trimethylated H3 lysine 4 (H3K4me3) is one of the most …

Sex chromosomes underlie the development of male or female sex organs across species.
While systemic signals derived from sex organs prominently contribute to sex-linked …

Hematopoietic mosaic loss of Y chromosome (mLOY) has emerged as a potential male‐
specific accelerator of biological aging, increasing the risk of various age‐related diseases …

Although cancer has long been considered a genetic disease, increasing evidence shows
that epigenetic aberrations play a crucial role in affecting tumor biology and therapeutic …

Signal transducer and activator of transcription 4 (STAT4) is a critical transcription factor for T
helper cell differentiation and tumor cells. Although its prognostic role and gene function …