Healthy mitochondria are essential for functional bioenergetics, calcium signaling, and
balanced redox homeostasis. Dysfunctional mitochondria are a central aspect of aging and …

Alzheimer's disease (AD) constitutes the most prominent form of dementia among elderly
individuals worldwide. Disease modeling using murine transgenic mice was first initiated …

Recent reports implicate gut microbiome dysbiosis in the onset and progression of
Alzheimer's disease (AD), yet studies involving model animals overwhelmingly omit the …

Corpora amylacea (CA) and their murine analogs, periodic acid Schiff (PAS) granules, are
age-related, carbohydrate-rich structures that serve as waste repositories for aggregated …

Alzheimer's disease (AD) is a neurodegenerative disease that affects a large proportion of
the aging population. RalBP1 (Rlip) is a stress-activated protein that plays a crucial role in …

Microglia-associated inflammation and miRNA dysregulation are key players in Alzheimer's
disease (AD) pathophysiology. Previously, we showed miR-124 upregulation in APP …

Amyloid-beta (Aβ) plays an important role in the pathogenesis of Alzheimer's disease.
Aberrant Aβ accumulation induces neuroinflammation, cerebrovascular alterations, and …

Over the past decades, significant efforts have been made to understand the precise
mechanisms underlying the pathogenesis of Alzheimer's disease (AD), the most common …

Background Genetic mutations underlying familial Alzheimer's disease (AD) were identified
decades ago, but the field is still in search of transformative therapies for patients. While …

Lipids play crucial roles in the susceptibility and brain cellular responses to Alzheimer's
disease (AD) and are increasingly considered potential soluble biomarkers in cerebrospinal …