Geroprotective interventions in the 3xTg mouse model of Alzheimer's disease
MM Sonsalla, DW Lamming - Geroscience, 2023 - Springer
Alzheimer's disease (AD) is an age-associated neurodegenerative disease. As the
population ages, the increasing prevalence of AD threatens massive healthcare costs in the …
population ages, the increasing prevalence of AD threatens massive healthcare costs in the …
[HTML][HTML] Mitochondria-sequestered Aβ renders synaptic mitochondria vulnerable in the elderly with a risk of Alzheimer disease
Mitochondria are critical for neurophysiology, and mitochondrial dysfunction constitutes a
characteristic pathology in both brain aging and Alzheimer disease (AD). Whether …
characteristic pathology in both brain aging and Alzheimer disease (AD). Whether …
High-Fat Diets in Animal Models of Alzheimer's Disease: How Can Eating Too Much Fat Increase Alzheimer's Disease Risk?
J Valentin-Escalera, M Leclerc… - Journal of Alzheimer's …, 2024 - content.iospress.com
High dietary intake of saturated fatty acids is a suspected risk factor for neurodegenerative
diseases, including Alzheimer's disease (AD). To decipher the causal link behind these …
diseases, including Alzheimer's disease (AD). To decipher the causal link behind these …
Rlip overexpression reduces oxidative stress and mitochondrial dysfunction in Alzheimer's disease: Mechanistic insights
PH Reddy, S Kshirsagar, C Bose… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disease that affects a large proportion of
the aging population. RalBP1 (Rlip) is a stress-activated protein that plays a crucial role in …
the aging population. RalBP1 (Rlip) is a stress-activated protein that plays a crucial role in …
Early cellular, molecular, morphological and behavioral changes in the humanized amyloid-beta-knock-in mouse model of late-onset Alzheimer's disease
The purpose of our study is to investigate early cellular, molecular, morphological and
behavioral changes in humanized amyloid-beta-knock-in (hAbKI) mice. Using seven-month …
behavioral changes in humanized amyloid-beta-knock-in (hAbKI) mice. Using seven-month …
Neuropathogenesis-on-chips for neurodegenerative diseases
S Amartumur, H Nguyen, T Huynh, TS Kim… - Nature …, 2024 - nature.com
Developing diagnostics and treatments for neurodegenerative diseases (NDs) is
challenging due to multifactorial pathogenesis that progresses gradually. Advanced in vitro …
challenging due to multifactorial pathogenesis that progresses gradually. Advanced in vitro …
Shared pathophysiology: Understanding stroke and Alzheimer's disease
S Sriram, Y Mehkri, S Quintin, B Lucke-Wold - Clinical Neurology and …, 2022 - Elsevier
Alzheimer's disease and stroke share several known vascular risk factors. The
pathophysiology and whether one predisposes to the other is a topic of ongoing …
pathophysiology and whether one predisposes to the other is a topic of ongoing …
Nonrespiratory sites of influenza‐associated disease: mechanisms and experimental systems for continued study
HM Froggatt, NS Heaton - The FEBS journal, 2022 - Wiley Online Library
The productive replication of human influenza viruses is almost exclusively restricted to cells
in the respiratory tract. However, a key aspect of the host response to viral infection is the …
in the respiratory tract. However, a key aspect of the host response to viral infection is the …
Human stem cell transplantation models of Alzheimer's disease
N Ifediora, P Canoll, G Hargus - Frontiers in Aging Neuroscience, 2024 - frontiersin.org
Alzheimer's disease (AD) is the most frequent form of dementia. It is characterized by
pronounced neuronal degeneration with formation of neurofibrillary tangles and deposition …
pronounced neuronal degeneration with formation of neurofibrillary tangles and deposition …
Neuronal transplantation for Alzheimer's disease and prospects for generating exogenic neurons as a source of cells for implantation
P Strell, ST Johnson, C Carchi… - Cell …, 2023 - journals.sagepub.com
Alzheimer's disease (AD) is a devastating neurodegenerative disease with limited
therapeutic options. Cellular transplantation of healthy exogenic neurons to replace and …
therapeutic options. Cellular transplantation of healthy exogenic neurons to replace and …