Over the past decades, significant efforts have been made to understand the precise
mechanisms underlying the pathogenesis of Alzheimer's disease (AD), the most common …

We investigated the genome of a 5-year-old male who presented with global developmental
delay (motor, cognitive, and speech), hypotonia, possibly ataxia, and cerebellar hypoplasia …

Down syndrome (DS) is the most common chromosomal abnormality and leads to
intellectual disability, increased risk of cardiac defects, and an altered immune response …

Age is the largest risk factor for developing Alzheimer's disease (AD), a neurodegenerative
disorder that causes a progressive and severe dementia. The underlying cause of cognitive …

Although a large number of mouse models have been made to study Alzheimer's disease,
only a handful allow experimental control over the location or timing of the protein being …

Functional magnetic resonance imaging faces inherent challenges when applied to deep-
brain areas in rodents, eg entorhinal cortex, due to the signal loss near the ear cavities …

Cholesterol is essential for cellular function and is stored as cholesteryl esters (CEs). CEs
biosynthesis is catalyzed by the enzymes acyl-CoA: cholesterol acyltransferase 1 and 2 …

Alzheimer's disease (AD) is an incurable, age-related and progressive neurodegenerative
disease characterized by cognitive impairments. Deficits in synaptic plasticity were reported …

There are an estimated 6 million people with Down syndrome (DS) worldwide. In developed
countries, the vast majority of these individuals will develop Alzheimer's disease …

Background: Alzheimer's disease (AD) research has relied on mouse models
overexpressing human mutant A βPP; however, newer generation knock-in models allow for …