[HTML][HTML] A small molecule p38α MAPK inhibitor, MW150, attenuates behavioral deficits and neuronal dysfunction in a mouse model of mixed amyloid and vascular …
HN Frazier, DJ Braun, CS Bailey, MJ Coleman… - Brain, Behavior, & …, 2024 - Elsevier
Background Inhibition of p38 alpha mitogen activated protein kinase (p38α) has shown
great promise as a treatment for Alzheimer's disease (AD) in preclinical tests. However …
great promise as a treatment for Alzheimer's disease (AD) in preclinical tests. However …
Rodent Modeling of Alzheimer's Disease in Down Syndrome: In vivo and ex vivo Approaches
C Farrell, P Mumford, FK Wiseman - Frontiers in Neuroscience, 2022 - frontiersin.org
There are an estimated 6 million people with Down syndrome (DS) worldwide. In developed
countries, the vast majority of these individuals will develop Alzheimer's disease …
countries, the vast majority of these individuals will develop Alzheimer's disease …
Mitochondrial Alterations in Neurons Derived from the Murine App NL-F Knock-In Model of Alzheimer's Disease
Background: Alzheimer's disease (AD) research has relied on mouse models
overexpressing human mutant A βPP; however, newer generation knock-in models allow for …
overexpressing human mutant A βPP; however, newer generation knock-in models allow for …
Genetically modified mice for research on human diseases: A triumph for Biotechnology or a work in progress?
RE Brown - The EuroBiotech Journal, 2022 - sciendo.com
Genetically modified mice are engineered as models for human diseases. These mouse
models include inbred strains, mutants, gene knockouts, gene knockins, and …
models include inbred strains, mutants, gene knockouts, gene knockins, and …
Inbred mice again at stake: how the cognitive profile of the wild-type mouse background discloses pathogenic effects of APP mutations
M Ammassari-Teule - Frontiers in Behavioral Neuroscience, 2022 - frontiersin.org
Increasing efforts have been made in the last decades to increase the face validity of
Alzheimer's disease (AD) mouse models. Main advancements have consisted in generating …
Alzheimer's disease (AD) mouse models. Main advancements have consisted in generating …
Improving mouse models for the study of Alzheimer's disease
AM Reagan, KD Onos, SE Heuer, M Sasner… - Current topics in …, 2022 - Elsevier
Alzheimer's disease (AD) is a complex neurodegenerative disease whose risk is influenced
by genetic and environmental factors. Although a number of pathological hallmarks have …
by genetic and environmental factors. Although a number of pathological hallmarks have …
Astrocyte-derived MFG-E8 facilitates microglial synapse elimination in Alzheimer's disease mouse models
D Sokolova, S Addington Ghansah, F Puletti… - bioRxiv, 2024 - biorxiv.org
Region-specific synapse loss is an early pathological hallmark in Alzheimer's disease (AD).
Emerging data in mice and humans highlight microglia, the brain-resident macrophages, as …
Emerging data in mice and humans highlight microglia, the brain-resident macrophages, as …
Differential neural circuit vulnerability to β-amyloid and tau pathologies in novel Alzheimer's disease mice
MD Capilla-López, A Deprada, Y Andrade-Talavera… - bioRxiv, 2023 - biorxiv.org
Alzheimer's disease (AD) progresses with memory loss and neuropsychiatric symptoms
associated with cell specific vulnerability in memory-and emotion-related neural circuits …
associated with cell specific vulnerability in memory-and emotion-related neural circuits …
Elevated Ghrelin Promotes Hippocampal Ghrelin Receptor Defects in Humanized Amyloid-β Knockin Mice During Aging
J Tian, E Du, K Jia, T Wang, L Guo… - Journal of …, 2023 - content.iospress.com
Background: Emerging evidence has revealed that dysregulation of the hormone ghrelin
and its receptor, growth hormone secretagogue receptor (GHSR), contributes to the …
and its receptor, growth hormone secretagogue receptor (GHSR), contributes to the …
[HTML][HTML] Polyglucosan body density in the aged mouse hippocampus is controlled by a novel modifier locus on chromosome 1
Aging can be associated with the accumulation of hypobranched glycogen molecules
(polyglucosan bodies, PGBs), particularly in astrocytes of the hippocampus. While PGBs …
(polyglucosan bodies, PGBs), particularly in astrocytes of the hippocampus. While PGBs …